KORELASI NILAI AUTOLOGOUS PLASMA SKIN TEST DAN SERUM C-REACTIVE PROTEIN PADA URTIKARIA KRONIS SPONTAN
DOI:
https://doi.org/10.33820/mdvi.v51i1.422Keywords:
urtikaria kronis spontan, autologous plasma skin test, c-reactive proteinAbstract
Urtikaria Kronis Spontan (UKS) berdampak signifikan pada kualitas hidup pasien. Autologous Plasma Skin Test (APST) dan C-reactive protein (CRP) merupakan skrining praktis pada UKS. Hasil positif disebab- kan oleh sitokin inflamatorik saat degranulasi sel mast dan dapat berkorelasi dengan keparahan UKS. Studi analitik observasional dengan desain potong-lintang dilakukan selama bulan Juli-September 2021 melibatkan lima puluh pasien UKS berusia 17-51 tahun. Keparahan penyakit dinilai menggunakan Urticaria Activity Score (UAS7). Hasil APST dinilai berdasarkan kriteria Sabroe. Nilai serum CRP diukur menggunakan high sensitiv- ity CRP (hsCRP). Hasil APST positif ditemukan pada hampir semua pasien (95%) dan hanya empat pasien dengan CRP positif (8%). Keparahan berkorelasi bermakna terhadap diameter urtika (P = 0,038) dan nilai CRP (P = 0,041). Analisis odds ratio (OR) menunjukkan bahwa pasien dengan hasil APST positif memiliki risiko 32 kali mengalami UKS sedang-berat. Tidak ditemukan korelasi bermakna antara nilai APST dan serum CRP pada UKS.
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References
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21. Asero R, Tedeschi A, Coppola R, Griffini S, Paparella P, Riboldi P, et al. Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria. J Allergy Clin Immunol. 2007;119(3):705–10.
22. Stepaniuk P, Kan M, Kanani A. Natural history, prognostic factors and patient perceived response to treatment in chronic spontaneous urticaria. Allergy Asthma Clin Immunol. 2020;16(1):1–11.
23. Jo YH, Yoo HW, Kim SH, Kim YM, Kim H, Kim H. Clinical characteristics and treatment response of chronic spontaneous urticaria according to age: A single-center Korean study. Asian Pac J Allergy Immunol. 2021;9–13.
24. Adil MCL, Nopriyati N, Oktariana D, Kurniawati Y, Prasasty GD. Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients. Sriwij J Med. 2021;4(1):24–9.
25. Rafikasari A, Fetarayani D, Setyaningrum T. Profil Pasien Urtikaria (Profile of Urticaria Patients). Period Dermatol Venereol. 2019;31(3):222–7.
26. Kim YS, Park SH, Han K, Lee JH, Kim NI, Roh JY, et al. Clinical course of chronic spontaneous urticaria in the Korean adult population. Allergy Asthma Immunol Res. 2018;10(1):83–7.
27. Parisi CA, Ritchie C, Petriz N, Torres CM, Gimenez-Arnau A. Chronic urticaria in a health maintenance organization of buenos aires, Argentina – New data that increase global knowledge of this disease. An Bras Dermatol. 2018;93(1):76–9.
28. Thomsen S, Pritzier E, Vaugelade-Baust N, Dodge R, Dahlborn A, Vestergaard C. Chronic urticaria in the real-life clinical practice setting in Sweden, Norway and Denmark: Baseline results from the non-interventional multicentre AWARE study. J Eur Acad Dermatol Venereol. 2017;31(6):1048–55.
29. Guillet G, Bécherel PA, Pralong P, Delbarre M, Outtas O, Martin L, et al. The burden of chronic urticaria: French baseline data from the international real-life AWARE study. Eur J Dermatol. 2019;29(1):49–54.
30. Kasperska-Zajac A, Brzoza Z, Rogala B. Sex hormones and urticaria. J Dermatol. 2008;52(2):79–86.
31. Bernstein JA, Bouillet L, Caballero T, Staevska M. Hormonal Effects on Urticaria and Angioedema Conditions. J Allergy Clin Immunol Pr. 2021;9(6):2209–19.
32. Hawro T, Ohanyan T, Schoepke N, Metz M, Peveling-Oberhag A, Staubach P, et al. The Urticaria Activity Score—Validity, Reliability, and Responsiveness. J Allergy Clin Immunol Pr. 2018;6(4):1185-1190.e1.
33. Hollis K, Proctor C, McBride D, Balp MM, McLeod L, Hunter S, et al. Comparison of Urticaria Activity Score Over 7 Days (UAS7) Values Obtained from Once-Daily and Twice-Daily Versions: Results from the ASSURE-CSU Study. Am J Clin Dermatol. 2018;19(2):267–74.
34. Nakatani S, Oda Y, Washio K, Fukunaga A, Nishigori C. The Urticaria Control Test and Urticaria Activity Score correlate with quality of life in adult Japanese patients with chronic spontaneous urticaria. Allergol Int. 2019;68(2):279–81.
35. Costa C, Rosmaninho I, Guilherme A, Ferreira J, Antunes J, Pina A, et al. Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal : Baseline Results from the Non-Interventional. Acta Med Port. 2019;32(2):133–40.
36. Yanase Y, Takahagi S, Ozawa K, Hide M. The role of coagulation and complement factors for mast cell activation in the pathogenesis of chronic spontaneous urticaria. Cells. 2021;10(7):1–10.
37. Asero R, Tedeschi A, Marzano A V., Cugno M. Chronic spontaneous urticaria: Immune system, blood coagulation, and more. Expert Rev Clin Immunol. 2016;12(3):229–31.
38. Sakurai Y, Morioke S, Takeda T, Takahagi S, Hide M, Shima M. Increased thrombin generation potential in patients with chronic spontaneous urticaria. Allergol Int. 2015;64(1):96–8.
39. Ansar W, Ghosh S. Pathobiological Role of CRP in Diseases: Clinical Medical Applications of CRP. In: Ansar W, Ghosh S, editors. Biology of C Reactive Protein in Health and Disease. 1st ed. India: Springer India; 2016. p. 133–42.
40. Karabay E, Çerman A, Altunay I. Serum C-reactive protein, neutrophil-lymphocyte ratio and uric acid levels in chronic spontaneous urticaria. Turkiye Klin J Dermatol. 2016;26(3):125–31.
41. Sim D, Yu J, Koh Y. Inflammation markers are associated with disease activity in patients with chronic urticaria. J Allergy Clin Immunol. 2019;143(2):AB51.
42. Boonpiyathad T, Sangasapaviliya A. Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria. Asia Pac Allergy. 2016;6(4):226–35.
43. Chanprapaph K, Iamsumang W, Wattanakrai P, Vachiramon V. Thyroid autoimmunity and autoimmunity in chronic spontaneous urticaria linked to disease severity, therapeutic response, and time to remission in patients with chronic spontaneous urticaria. BioMed Res Int. 2018;1–14.
44. Montjoye L, Darrigade AS, Gimenez Arnau A, Herman A, Dumoutier L, Baeck M. Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2021;53(2):55–66.
45. Kasperska-Zajac A, Grzanka A, Damasiewicz-Bodzek A. IL-6 transsignaling in patients with chronic spontaneous urticaria. PLoS One. 2015;10(12):1–9.
46. Rajappa M, Chandrashekar L, Sundar I, Munisamy M, Ananthanarayanan PH, Thappa DM, et al. Platelet oxidative stress and systemic inflammation in chronic spontaneous urticaria. Clin Chem Lab Med. 2013;51(9):1789–94.
47. Varghese R, Rajappa M, Chandrashekar L, Kattimani S, Archana M, Munisamy M, et al. Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria. Ann Allergy Asthma Immunol. 2016;116(4):344–8.
48. Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun. 2018;70:61–75.
49. Park GH, Choi JH, Kim S, Bae Y. The relation of autologous serum skin test and autologous plasma skin test result with various clinical and laboratory findings in patients with chronic spontaneous urticaria. Ann Dermatol. 2020;32(4):280–8.
50. Krystel-Whittemore M, Dileepan KN, Wood JG. Mast cell: A multi-functional master cell. Front Immunol. 2016;6(JAN):1–12.
51. Giménez-Arnau AM, DeMontojoye L, Asero R, Cugno M, Kulthanan K, Yanase Y, et al. The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells. J Allergy Clin Immunol Pr. 2021;9(6):2195–208.
2. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393–414.
3. Grattan CEH, Saini SS. Urticaria and Angioedema. In: Bolognia JL, Schaffer J V., Cerroni L, editors. Dermatology. 4th ed. Beijing: Elsevier Inc.; 2018. p. 304–19.
4. Chu CY, Al Hammadi A, Agmon-Levin N, Atakan N, Farag A, Arnaout RK, et al. Clinical characteristics and management of chronic spontaneous urticaria in patients refractory to H1-Antihistamines in Asia, Middle-East and Africa: Results from the AWARE-AMAC study. World Allergy Organ J. 2020;13(4):1001–17.
5. Curto-Barredo L, Riba Archilla L, Roura Vives G, Pujol RM, Giménez-Arnau AM. Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment. Acta Derm Venereol. 2018;98(7):641–7.
6. Fricke J, Ãvila G, Keller T, Weller K, Lau S, Maurer M, et al. Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta-analysis. Allergy. 2020;75(2):423–32.
7. Saini SS, Kaplan AP. Chronic Spontaneous Urticaria: The Devil’s itch. J Allergy Clin Immunol Pr. 2018;6(4):1097–106.
8. Jain S. Pathogenesis of chronic urticaria: An overview. Dermatol Res Pr. 2014;2014:1–11.
9. Asero R, Tedeschi A, Marzano AV, Cugno M. Chronic urticaria: A focus on pathogenesis. F1000Res. 2017;6:1–7.
10. Kolkhir P, Church MK, Weller K, Metz M, Schmetzer O, Maurer M. Autoimmune chronic spontaneous urticaria: What we know and what we do not know. J Allergy Clin Immunol. 2017;139(6):1772-1781.e1.
11. Dogheim N, Gheida S, Ghaly N, Ibrahim M, El-Enein AA. Chronic idiopathic urticaria: autologous skin tests and treatment. Egypt J Dermatol Venereol. 2014;34(1):46–52.
12. Kumaran MS, Mangal S, Narang T, Parsad D. Autologous serum and plasma skin tests in chronic spontaneous urticaria: A reappraisal. Indian Dermatol Online J. 2017;8(2):94–9.
13. Asero R, Tedeschi A, Riboldi P, Cugno M. Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum. J Allergy Clin Immunol. 2006;117(5):1113–7.
14. Tedeschi A, Kolkhir P, Asero R, Pogorelov D, Olisova O, Kochergin N, et al. Chronic urticaria and coagulation: Pathophysiological and clinical aspects. Allergy. 2014;69(6):683–91.
15. Cugno M, Marzano A V., Asero R, Tedeschi A. Activation of blood coagulation in chronic urticaria: Pathophysiological and clinical implications. Intern Emerg Med. 2010;5(2):97–101.
16. Kasperska-Zajac A. Acute-phase response in chronic urticaria. J Euro Acad Dermatol Venereol. 2012;26(6):665–72.
17. Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front Immunol. 2018;9(4):1–11.
18. Rathod D, Malkani R, Jadhav K, Gole P. Dermatology assessment of C Reactive Protein in chronic urticaria as a marker of disease activity and underlying systemic inflammation: a Case control study. Sch J App Med Sci. 2018;6(1A):5–9.
19. Maouia A, Youssef M, Leban N, Ben Chibani J, Helal AN, Kassab A. CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients. Cutan Ocul Toxicol. 2017;36(4):387–92.
20. Grzanka R, Damasiewicz-Bodzek A, Kasperska-Zajac A. Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria. Allergy Asthma Clin Immunol. 2018;14:1–8.
21. Asero R, Tedeschi A, Coppola R, Griffini S, Paparella P, Riboldi P, et al. Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria. J Allergy Clin Immunol. 2007;119(3):705–10.
22. Stepaniuk P, Kan M, Kanani A. Natural history, prognostic factors and patient perceived response to treatment in chronic spontaneous urticaria. Allergy Asthma Clin Immunol. 2020;16(1):1–11.
23. Jo YH, Yoo HW, Kim SH, Kim YM, Kim H, Kim H. Clinical characteristics and treatment response of chronic spontaneous urticaria according to age: A single-center Korean study. Asian Pac J Allergy Immunol. 2021;9–13.
24. Adil MCL, Nopriyati N, Oktariana D, Kurniawati Y, Prasasty GD. Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients. Sriwij J Med. 2021;4(1):24–9.
25. Rafikasari A, Fetarayani D, Setyaningrum T. Profil Pasien Urtikaria (Profile of Urticaria Patients). Period Dermatol Venereol. 2019;31(3):222–7.
26. Kim YS, Park SH, Han K, Lee JH, Kim NI, Roh JY, et al. Clinical course of chronic spontaneous urticaria in the Korean adult population. Allergy Asthma Immunol Res. 2018;10(1):83–7.
27. Parisi CA, Ritchie C, Petriz N, Torres CM, Gimenez-Arnau A. Chronic urticaria in a health maintenance organization of buenos aires, Argentina – New data that increase global knowledge of this disease. An Bras Dermatol. 2018;93(1):76–9.
28. Thomsen S, Pritzier E, Vaugelade-Baust N, Dodge R, Dahlborn A, Vestergaard C. Chronic urticaria in the real-life clinical practice setting in Sweden, Norway and Denmark: Baseline results from the non-interventional multicentre AWARE study. J Eur Acad Dermatol Venereol. 2017;31(6):1048–55.
29. Guillet G, Bécherel PA, Pralong P, Delbarre M, Outtas O, Martin L, et al. The burden of chronic urticaria: French baseline data from the international real-life AWARE study. Eur J Dermatol. 2019;29(1):49–54.
30. Kasperska-Zajac A, Brzoza Z, Rogala B. Sex hormones and urticaria. J Dermatol. 2008;52(2):79–86.
31. Bernstein JA, Bouillet L, Caballero T, Staevska M. Hormonal Effects on Urticaria and Angioedema Conditions. J Allergy Clin Immunol Pr. 2021;9(6):2209–19.
32. Hawro T, Ohanyan T, Schoepke N, Metz M, Peveling-Oberhag A, Staubach P, et al. The Urticaria Activity Score—Validity, Reliability, and Responsiveness. J Allergy Clin Immunol Pr. 2018;6(4):1185-1190.e1.
33. Hollis K, Proctor C, McBride D, Balp MM, McLeod L, Hunter S, et al. Comparison of Urticaria Activity Score Over 7 Days (UAS7) Values Obtained from Once-Daily and Twice-Daily Versions: Results from the ASSURE-CSU Study. Am J Clin Dermatol. 2018;19(2):267–74.
34. Nakatani S, Oda Y, Washio K, Fukunaga A, Nishigori C. The Urticaria Control Test and Urticaria Activity Score correlate with quality of life in adult Japanese patients with chronic spontaneous urticaria. Allergol Int. 2019;68(2):279–81.
35. Costa C, Rosmaninho I, Guilherme A, Ferreira J, Antunes J, Pina A, et al. Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal : Baseline Results from the Non-Interventional. Acta Med Port. 2019;32(2):133–40.
36. Yanase Y, Takahagi S, Ozawa K, Hide M. The role of coagulation and complement factors for mast cell activation in the pathogenesis of chronic spontaneous urticaria. Cells. 2021;10(7):1–10.
37. Asero R, Tedeschi A, Marzano A V., Cugno M. Chronic spontaneous urticaria: Immune system, blood coagulation, and more. Expert Rev Clin Immunol. 2016;12(3):229–31.
38. Sakurai Y, Morioke S, Takeda T, Takahagi S, Hide M, Shima M. Increased thrombin generation potential in patients with chronic spontaneous urticaria. Allergol Int. 2015;64(1):96–8.
39. Ansar W, Ghosh S. Pathobiological Role of CRP in Diseases: Clinical Medical Applications of CRP. In: Ansar W, Ghosh S, editors. Biology of C Reactive Protein in Health and Disease. 1st ed. India: Springer India; 2016. p. 133–42.
40. Karabay E, Çerman A, Altunay I. Serum C-reactive protein, neutrophil-lymphocyte ratio and uric acid levels in chronic spontaneous urticaria. Turkiye Klin J Dermatol. 2016;26(3):125–31.
41. Sim D, Yu J, Koh Y. Inflammation markers are associated with disease activity in patients with chronic urticaria. J Allergy Clin Immunol. 2019;143(2):AB51.
42. Boonpiyathad T, Sangasapaviliya A. Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria. Asia Pac Allergy. 2016;6(4):226–35.
43. Chanprapaph K, Iamsumang W, Wattanakrai P, Vachiramon V. Thyroid autoimmunity and autoimmunity in chronic spontaneous urticaria linked to disease severity, therapeutic response, and time to remission in patients with chronic spontaneous urticaria. BioMed Res Int. 2018;1–14.
44. Montjoye L, Darrigade AS, Gimenez Arnau A, Herman A, Dumoutier L, Baeck M. Correlations between disease activity, autoimmunity and biological parameters in patients with chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2021;53(2):55–66.
45. Kasperska-Zajac A, Grzanka A, Damasiewicz-Bodzek A. IL-6 transsignaling in patients with chronic spontaneous urticaria. PLoS One. 2015;10(12):1–9.
46. Rajappa M, Chandrashekar L, Sundar I, Munisamy M, Ananthanarayanan PH, Thappa DM, et al. Platelet oxidative stress and systemic inflammation in chronic spontaneous urticaria. Clin Chem Lab Med. 2013;51(9):1789–94.
47. Varghese R, Rajappa M, Chandrashekar L, Kattimani S, Archana M, Munisamy M, et al. Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria. Ann Allergy Asthma Immunol. 2016;116(4):344–8.
48. Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun. 2018;70:61–75.
49. Park GH, Choi JH, Kim S, Bae Y. The relation of autologous serum skin test and autologous plasma skin test result with various clinical and laboratory findings in patients with chronic spontaneous urticaria. Ann Dermatol. 2020;32(4):280–8.
50. Krystel-Whittemore M, Dileepan KN, Wood JG. Mast cell: A multi-functional master cell. Front Immunol. 2016;6(JAN):1–12.
51. Giménez-Arnau AM, DeMontojoye L, Asero R, Cugno M, Kulthanan K, Yanase Y, et al. The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells. J Allergy Clin Immunol Pr. 2021;9(6):2195–208.
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Published
2024-02-26
How to Cite
Garfendo, G., Husan, N., Yahya, Y. F., Bahar, E., Thaha, M. A., & Kurniawati, Y. (2024). KORELASI NILAI AUTOLOGOUS PLASMA SKIN TEST DAN SERUM C-REACTIVE PROTEIN PADA URTIKARIA KRONIS SPONTAN. Media Dermato-Venereologica Indonesiana, 51(1), 2–8. https://doi.org/10.33820/mdvi.v51i1.422
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