PIODERMA GANGRENOSUM MULTIPEL DAN BERULANG

Authors

  • Alida Widiawaty
  • Farah Asyuri Yasmin
  • Ilhami Romus

DOI:

https://doi.org/10.33820/mdvi.v49i2.337

Keywords:

kekambuhan, multipel pioderma gangrenosum, ulkus

Abstract

Pyoderma gangrenosum is a rare, non-infectious inflammatory skin disease. Diagnosis and treatment are challenging since there are no specific diagnostic criteria or gold standard therapy. The case of a 73 years old man, consulted by surgery department with painful and  rapidly progressive necrotic ulcer on his left lower limb and right arm. The initial diagnosis was bacterial ulcer, he underwent debridement and received antibiotics. In the few days, his wound had worsened with enhanced in size and extremely painful. Histological examination showed a dense dermal infiltrate of neutrophil (predominant), lymphocyte, and plasma cell; conformable to pyoderma gangrenosum. Injection of methylprednisolone 31.25 mg /  day and mometasone furoate cream 0.1%  was given. Clinical improvement was noted in 2 weeks after therapy. Two years later, he developed typical necrotic ulcer on right limb. Pyoderma gangrenosum must be considered in any patient with painful and rapidly progressive ulcer that do not respond to broad-spectrum antibiotics. The histological findings can rule out the other causes of cutaneous ulcer. Suppression of  inflammatory process is the main goal in therapy. The delay in identify, inappropriate treatment, and recurrence of the disease remain an issue.

Downloads

Download data is not yet available.

References

1. George C, Deroide F, Rustin M. Pyoderma gangreno- sum–a guide to diagnosis and management. Clin Med. 2019;19(3):224-8.
2. Ahsan MK. Pyoderma Gangrenosum: An enigma without a cure? Bangladesh Crit Care J. 2019;7(2):99-101.
3. Shavit E, Alavi A, Sibbald RG. Pyoderma gangrenosum: a critical appraisal. Adv Skin Wound Care. 2017;30(12):534- 42.
4. Jourabchi N, Lazarus GS. Pyoderma Gangrenosum. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMi- chael AJ, et al., editors. FItzpatrick’s Dermatology. 9th ed. New York: McGraw-Hill; 2019. h. 605 - 15.
5. Lemos AC, Aveiro D, Santos N, Marques V, Pinheiro LF. Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature. Wounds. 2017;29(9):E61-E9.
6. Saffie MG, Shroff A. A case of pyoderma gangrenosum mis- diagnosed as necrotizing infection: a potential diagnostic ca- tastrophe. Case Rep Infect Dis. 2018;2018:1-5.
7. Vasnik GK, Chittoria RS, Jain G, Bhattacharya S. Case report of ulcerative pyoderma gangrenosum of the forearm: A chal- lenging diagnosis. Indian J Case Reports. 2020:188-90.
8. Jain AG, Sharbatji M, Afzal A, Afridi SM, Gordon D. Pyoder-
ma gangrenosum in the absence of any underlying predispos-
ing condition: a diagnostic dilemma. Cureus. 2019;11(3):1-6. 9. Fletcher J, Alhusayen R, Alavi A. Recent advances in man- aging and understanding pyoderma gangrenosum. F1000Re-
search. 2019;8:1-12.
10. Young T. Understanding pyoderma gangrenosum. Wounds
UK. 2018;14(5):87-91.
11. Galimberti RL, Vacas AS, Garlatti MLB, Torre AC. The role
of interleukin-1β in pyoderma gangrenosum. JAAD Case
Rep. 2016;2(5):366-8.
12. Almukhtar R, Armenta AM, Martin J, Goodwin BP, Vincent
B, Lee B, dkk. Delayed diagnosis of post-surgical pyoderma gangrenosum: a multicenter case series and review of litera- ture. Int J Surg Case Rep. 2018;44:152-6.
13. Xia FD, Liu K, Lockwood S, Butler D, Tsiaras WG, Joyce C, dkk. Risk of developing pyoderma gangrenosum after pro- cedures in patients with a known history of pyoderma gan- grenosum—a retrospective analysis. J Am Acad Dermatol. 2018;78(2):310-4. e1.
14. Haag CK, Bacik L, Latour E, Morse DC, Fett NM, Ortega- Loayza AG. Perioperative management of pyoderma gan- grenosum. J Am Acad Dermatol. 2020;83(2):369-74.

Published

2023-02-20

How to Cite

Widiawaty, A., Yasmin, F. A., & Romus, I. (2023). PIODERMA GANGRENOSUM MULTIPEL DAN BERULANG. Media Dermato-Venereologica Indonesiana, 49(2), 86–90. https://doi.org/10.33820/mdvi.v49i2.337