MALFORMASI VENA VERUKOSA: PERKEMBANGAN DIAGNOSIS DAN TATA LAKSANA
DOI:
https://doi.org/10.33820/mdvi.v49i2.336Keywords:
hiperkeratotik, malformasi vascular, malformasi vena verukosa, MAP3K3, tata laksanaAbstract
Verrucous venous malformation (VVM), formerly known as verrucous hemangioma, is a rare, congenital, non-hereditary vascular malformation. The initial clinical manifestations of VVM include bluish patches that become erythematous to purplish, then enlarge slowly to become verrucous and hyperkeratotic papules, plaques, or nodules. Its etiopathogenesis remain unknown. It used to be one of unclassified vascular anomalies due to its clinical feature consistent with malformations, but shows positive results on immunohistochemical for tumors. The identification of somatic mutations in the mitogen-activated protein kinase 3 (MAP3K3) gene has classified it into venous malformation group. Clinically this lesion often resembles other diseases that may lead to misdiagnosis. Investigations such as dermoscopy, radiology, histopathology, and immunohistochemical are continually updated as new cases are found. Superficial ablative procedures often result in recurrence of the lesions. There is potential for targeted therapy using sirolimus but surgical excision remain preferred choice. Early diagnosis and prompt treatment are important due to the risk of recurrence.
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References
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2. ISSVA General Assembly, classification for vascular anoma- lies. Amsterdam:ISSVA, 2018;1–14.
3. Couto JA, Vivero MP, Kozakewich HPW, Taghinia AH, Mul- liken JB, Warman ML, dkk. A somatic MAP3K3 mutation is associated with verrucous venous malformation. Am J Hum Genet. 2015;96(3):480–6.
4. Zhang G, Chen H, Zhen Z, Chen J, Zhang S, Qin Q, dkk. Sirolimus for treatment of verrucous venous malforma- tion: A retrospective cohort study. J Am Acad Dermatol. 2019;80(2):556–8.
5. Zúñiga-Castillo M, Teng CL, Teng JMC. Genetics of vascular malformation and therapeutic implications. Curr Opin Pedi- atr. 2019;31(4):498–508.
6. Paolacci S, Zulian A, Bruson A, Manara E, Michelini S, Mattassi RE, dkk. Vascular anomalies: Molecular bases, genetic testing and therapeutic approaches. Int Angiol. 2019;38(2):157–70.
7. Bly RA, Shivaram G, Monroe EJ. Venous malformations. Dalam: Perkins JA, Balakrishnan K, penyunting. Evidence- based management of head and neck vascular anomalies. Springer International Publishing; 2018. h.171–8.
8. Laun K, Laun J, Smith D. Verrucous hemangioma. Eplasty. 2019;19:ic1.
9. Boon LM, Ballieux F, Vikkula M. Vascular malformations. Dalam: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichae AJ, dkk., penyunting. Fitzpatrick’s Dermatol- ogy. Edisi ke-9. New York: McGraw-Hill; 2019. h. 2636–53.
10. Leavens J, Worswick S, Kim GH. Verrucous venous malfor- mation. Dermatol Online J. 2019;25(12):0–4.
11. Wang L, Gao T, Wang G. Verrucous hemangioma: A clinico- pathological and immunohistochemical analysis of 74 cases. J Cutan Pathol. 2014;41(11):823–30.
12. Beijnen UEA, Saldanha F, Ganske I, Upton J, Taghinia AH. Verrucous venous malformations of the hand. J Hand Surg (European Vol). 2019 Oct 1;44(8):850–5.
13. Dhanta A, Chauhan P, Meena D, Hazarika N. Linear verru- cous hemangioma—a rare case and dermoscopic clues to di- agnosis. Dermatol Pract Concept. 2018;8(1):43–7.
14. Nargis T, Pinto M, Bhat S, Shenoy M. M. Linear verrucous hemangioma of the upper limb: A rare case. Dermatol Online J. 2017;23(6):4–7.
15. Kale TP, Kotrashetti SM, Singh A. Extremely rare isolated and acquired oral presentation – Verrucous hemangioma. J Oral Maxillofac Surgery, Med Pathol. 2016;28(4):331–4.
16. Fatani M, Al Otaibi H, Mohammed M, Hegazy O. Verrucous hemangioma treated with electrocautery. Case Rep Dermatol. 2016;8(2):112–7.
17. Boccara O, Ariche-Maman S, Hadj-Rabia S, Chrétien-Mar- quet B, Frassati-Biaggi A, Zazurca F, dkk. Verrucous hem- angioma (also known as verrucous venous malformation): A vascular anomaly frequently misdiagnosed as a lymphatic malformation. Pediatr Dermatol. 2018;35(6):e378–81.
18. Wang L, Yuan W, Geng S, Xiong Y, Zhang D, Zhao X, dkk. Expression of lymphatic markers in angiokeratomas. J Cutan Pathol. 2014;41(7):576–81.
19. MacArthur KM, Puttgen K. Vascular tumors. Dalam: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, dkk., penyunting. Fitzpatrick’s Dermatology. Edisi ke-9. New York; 2019. h. 2042–59.
20. Singh J, Sharma P, Tandon S, Sinha S. Multiple verrucous hemangiomas: A case report with new therapeutic insight. In-dian Dermatol Online J. 2017;8(4):254.
21. Zaballos P, del Pozo LJ, Argenziano G, Karaarslan IK, Landi
C, Vera A, dkk. Dermoscopy of lymphangioma circumscrip- tum: A morphological study of 45 cases. Australas J Derma- tol. 2018;59(3):e189–93.
22. Marghoob NG, Liopyris K, Jaimes N. Dermoscopy: A review of the structures that facilitate melanoma detection. J Am Os- teopath Assoc. 2019;119(6):380–90.
23. Sadick M, Overhoff D, Baessler B, Von Spangenberg N, Krebs L, Wohlgemuth WA. Peripheral vascular anomalies - essen- tials in periinterventional imaging. RoFo. 2020;192(2):150– 62.
24. Wortsman X. Atlas of Dermatologic ultrasound. Springer In- ternational Publishing; 2018. h.85–113.
25. Nagarajan K, Banushree C. Usefulness of MRI in delineation of dermal and subcutaneous verrucous hemangioma. Indian J Dermatol. 2015;60(5):525.
26. van Vugt LJ, van der Vleuten CJM, Flucke U, Blokx WAM. The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommenda- tions for daily practice. Pathol Res Pract. 2017;213(6):591–7.
27. Segura Palacios JM, Boixeda P, Rocha J, González JA, Castro LA, De Daniel RodrÃguez C. Laser treatment for verrucous hemangioma. Lasers Med Sci. 2012;27(3):681–4.
28. The 2011 Oxford CEBM levels of evidence. Howick J, Chalmers I, Glasziou P, Greenhalgh T, Heneghan C, Liberati A, dkk. OCEBM Levels of Evidence Working Group. Version 2.1. Oxford:2011.
29. Yang CH, Ohara K. Successful surgical treatment of ver- rucous hemangioma: A combined approach. Dermatologic Surg. 2002;28(10):913–20.
30. Patel PA, Barnacle AM, Stuart S, Amaral JG, John PR. En- dovenous laser ablation therapy in children: applications and outcomes. Pediatr Radiol. 2017;47(10):1353–63.
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Published
2023-02-20
How to Cite
Evyana, D., Wibawa, L. P., & Irawan, Y. (2023). MALFORMASI VENA VERUKOSA: PERKEMBANGAN DIAGNOSIS DAN TATA LAKSANA. Media Dermato-Venereologica Indonesiana, 49(2), 102–109. https://doi.org/10.33820/mdvi.v49i2.336
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