KOMORBIDITAS PADA AKNE
DOI:
https://doi.org/10.33820/mdvi.v49i2.334Keywords:
akne vulgaris, komorbiditasAbstract
- Akne vulgaris (AV) merupakan salah satu penyakit kulit yang paling sering ditemui, terutama pada remaja dan dewasa muda. Patogenesis terjadinya AV setidaknya diperankan oleh empat faktor penting, yaitu hiperproliferasi lapisan epidermis pada folikel, peningkatan produksi sebum, proses peradangan, dan kolonisasi Cutibacterium acnes. Proses tersebut juga dipengaruhi oleh berbagai faktor, antara lain faktor genetik, hormonal, psikologis, gaya hidup, dan lingkungan. Lesi AV bersifat polimorfik dan memiliki derajat keparahan yang beragam. Lesi tersebut diketahui memberikan dampak terhadap kualitas hidup penderitanya. Berbagai studi terkini melaporkan bahwa terdapat berbagai komorbiditas yang dapat memberikan beban tambahan atau memperburuk kondisi AV. Komorbiditas didefinisikan sebagai penyakit yang terjadi secara simultan. Berbeda dengan sindrom yang memiliki arti sekumpulan gejala yang terjadi serentak atau sekumpulan tanda yang menandakan suatu penyakit tertentu. Komorbiditas akne yang telah banyak diinvestigasi antara lain resistensi insulin, hipovitaminosis D, 1 hipervitaminosis B12, gangguan gastrointestinal, gangguan psikologis, disfungsi kelenjar tiroid, dislipidemia, defisiensi seng, dan hipovitaminosis A dan E.
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References
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20. Yan HM, Zhao HJ, Guo DY, Zhu PQ, Zhang CL, Jiang W. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018;45:1166–71.
21. Samuels DV, Rosenthal R, Lin R, Chaudhari S, Natsuaki MN. Acne vulgaris and risk of depression and anxiety: A meta- analytic review. J Am Acad Dermatol. 2020;83:532–41.
22. Singam V, Rastogi S, Patel KR, Lee HH, Silverberg JI. The mental health burden in acne vulgaris and rosacea: an analysis of the US national inpatient sample. Clin Exp Dermatol. 2019;44:766–72.
23. Stewart TJ, Bazergy C. Thyroid autoimmunity in female post- adolescent acne: A case-control study. Dermatoendocrinol. 2017;9:1–4.
24. Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6:27–35.
25. Sobhan M, Rabiei MAS, Amerifar M. Correlation between lipid profile and acne vulgaris. Clin Cosmet Investig
Dermatol. 2020;13:67–71.
26. Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels
and efficacy of zinc treatment in acne vulgaris: A systematic
review and meta-analysis. Dermatol Ther. 2020;33:1–8.
27. Nugraha H. Hubungan Kadar Seng Serum dengan Derajat Keparahan Akne Vulgaris berdasarkan Klasifikasi Lehmann dan dengan Jumlah Lesi Inflamasi. [Tesis]. Jakarta:
Universitas Indonesia; 2015.
28. Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I,
Kalkan G. Evaluation of serum vitamins A and e and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99–102.
29. Tunçez Akyürek F, Saylam Kurtipek G, Kurku H, Akyurek F, Unlu A, Abusoglu S, dkk. Assessment of ADMA, IMA, and vitamin A and E levels in patients with acne vulgaris. J Cosmet Dermatol. 2020;19:3408–13.
30. Fauziah SN. Korelasi kadar retinol serum dengan derajat keparahan akne vulgaris di RSUPN dr. Cipto Mangunkusumo kajian pola asupan vitamin A. [Tesis]. Jakarta: Universitas Indonesia; 2017.
2. Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, dkk. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134:1527–34.
3. Kubba R. Acne comorbidities. World Clin Dermatol. 2013;1:155–68.
4. Hasil Pencarian - KBBI Daring [Internet]. [dikutip 30 Desember 2020]. Tersedia pada: https://kbbi.kemdikbud. go.id/entri/komorbiditas.
5. Cong TX, Hao D, Wen X, Li XH, He G, Jiang X. From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res. 2019;311:337–49.
6. Kim H, Moon SY, Sohn MY, Lee WJ. Insulin-like growth factor-1 increases the expression of inflammatory biomarkers and sebum production in cultured sebocytes. Ann Dermatol. 2017;29:20–5.
7. González-Saldivar G, RodrÃguez-Gutiérrez R, Ocampo- Candiani J, González-González JG, Gómez-Flores M. Skin manifestations of insulin resistance: from a biochemical stance to a clinical diagnosis and management. Dermatol Ther (Heidelb). 2017;7:37–51.
8. Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133–223.
9. Balta I, Ekiz O, Ozuguz P, Ustun I, Karaca S, Dogruk Kacar S, dkk. Insulin resistance in patients with post-adolescent acne. Int J Dermatol. 2015;54:662–6.
10. Zinati-Saeed S, Shakiba E, Rahimi Z, Akbari M, Najafi F, Bahrehmand F, dkk. The insulin-like growth factor-1 (G>A) and 5,10-methylenetetrahydrofolate reductase (C677T) gene variants and the serum levels of insulin-like growth factor-1, insulin, and homeostasis model assessment in patients with acne vulgaris. Iran J Pathol. 2020;15:23–9.
11. Goel A, Sharma S, Kaur J, Bassi R, Tayade A. Insulin resistance in adult acne. IP Indian J Clin Exp Dermatology. 2019;5:202–5.
12. Hussain T, Tufail Si, Farooq P. Association of acne with metabolic syndrome and insulin resistance in young men. 2018;48:20–4.
13. Alhetheli G, Elneam AIA, Alsenaid A, Al-Dhubaibi M. Vitamin D levels in patients with and without acne and its relation to acne severity: A case-control study. Clin Cosmet Investig Dermatol. 2020;13:759–65.
14. Kemeriz F, Tuncer SÇ, Acar EM, Tuğrul B. Evaluation of 25-hydroxy vitamin D levels and disease severity in patients with acne vulgaris. Dermatol Ther. 2020;33:4–7.
15. Yahya S. Hubungan kadar 25-Hydroxyvitamin D serum dengan derajat keparahan, lesi inflamasi, dan lesi noninflamasi akne vulgaris pada pasien di poliklinik Kulit dan Kelamin, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo. [Tesis]. Jakarta: Universitas Indonesia: 2017.
16. Vitamin B12 - Health Professional Fact Sheet [Internet]. [dikutip 26 Januari 2021]. Tersedia pada: https://ods.od.nih. gov/factsheets/VitaminB12-HealthProfessional/#en5
17. Bs DHZ, Perez-sanchez A, Katta R. Acne related to dietary supplements. Dermatol Online J. 2020;26:4–10.
18. Kang D, SHi B, Erfe M, Craft N, Li H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Sci Transl Med. 2015;7:5–8.
19. Gökalp H, Bulur I, Gürer M. Decreased vitamin B12 and folic acid concentrations in acne patients after isotretinoin therapy: A controlled study. Indian J Dermatol. 2014;59:630.
20. Yan HM, Zhao HJ, Guo DY, Zhu PQ, Zhang CL, Jiang W. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018;45:1166–71.
21. Samuels DV, Rosenthal R, Lin R, Chaudhari S, Natsuaki MN. Acne vulgaris and risk of depression and anxiety: A meta- analytic review. J Am Acad Dermatol. 2020;83:532–41.
22. Singam V, Rastogi S, Patel KR, Lee HH, Silverberg JI. The mental health burden in acne vulgaris and rosacea: an analysis of the US national inpatient sample. Clin Exp Dermatol. 2019;44:766–72.
23. Stewart TJ, Bazergy C. Thyroid autoimmunity in female post- adolescent acne: A case-control study. Dermatoendocrinol. 2017;9:1–4.
24. Tanghetti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6:27–35.
25. Sobhan M, Rabiei MAS, Amerifar M. Correlation between lipid profile and acne vulgaris. Clin Cosmet Investig
Dermatol. 2020;13:67–71.
26. Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels
and efficacy of zinc treatment in acne vulgaris: A systematic
review and meta-analysis. Dermatol Ther. 2020;33:1–8.
27. Nugraha H. Hubungan Kadar Seng Serum dengan Derajat Keparahan Akne Vulgaris berdasarkan Klasifikasi Lehmann dan dengan Jumlah Lesi Inflamasi. [Tesis]. Jakarta:
Universitas Indonesia; 2015.
28. Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I,
Kalkan G. Evaluation of serum vitamins A and e and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99–102.
29. Tunçez Akyürek F, Saylam Kurtipek G, Kurku H, Akyurek F, Unlu A, Abusoglu S, dkk. Assessment of ADMA, IMA, and vitamin A and E levels in patients with acne vulgaris. J Cosmet Dermatol. 2020;19:3408–13.
30. Fauziah SN. Korelasi kadar retinol serum dengan derajat keparahan akne vulgaris di RSUPN dr. Cipto Mangunkusumo kajian pola asupan vitamin A. [Tesis]. Jakarta: Universitas Indonesia; 2017.
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Published
2023-02-20
How to Cite
Hardjodipuro, A. H., Astriningrum, R., Bernadette, I., Legiawati, L., & Widaty, S. (2023). KOMORBIDITAS PADA AKNE. Media Dermato-Venereologica Indonesiana, 49(2), 95–101. https://doi.org/10.33820/mdvi.v49i2.334
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Tinjauan Pustaka
