Peran Lactobacillus Pada Managemen Infeksi Endogen Genitalia Wanita
DOI:
https://doi.org/10.33820/mdvi.v45i2.22Abstract
Infeksi endogen genitalia wanita merupakan infeksi yang disebabkan oleh perubahan keseimbangan bakteri endogen vagina, termasuk bacterial vaginosis (BV) dan kandidiasis vulvovaginalis (KVV). Keduanya menyebabkan angka kejadian dan rekurensi yang tinggi, dan regimen terapi standar menunjukkan efektivitas yang bervariasi. Akhir-akhir ini Lactobacillus sebagai probiotik sering digunakan untuk terapi dan pencegahan rekurensi pada BV dan KVV. Lactobacillus merupakan flora normal dominan pada vagina, yang mampu menghasilkan asam laktat untuk menjaga pH normal, menghasilkan substansi antimikroba, menempel pada sel epitel vagina, dan menghambat pertumbuhan mikroba patogen. Penelitian menunjukkan efektivitas yang bervariasi dalam penggunaan Lactobacillus pada BV dan KVV, baik dalam bentuk sediaan oral ataupun intravagina. Lactobacillus efektif digunakan dalam pencegahan rekurensi BV, dan sebaiknya digunakan sebagai kombinasi bersama terapi antibiotika standar. Penelitian in vitro mendukung efektivitas Lactobacillus dalam inhibisi Candida, namun dibutuhkan lebih banyak penelitian klinis yang baik untuk dapat menjelaskan lebih lanjut efektivitas dan keamanan Lactobacillus untuk terapi KVV.
Kata kunci: Lactobacillus, Bacterial Vaginosis, Kandidiasis Vulvovaginalis, rekurensi
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References
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Mosca L, Perluigi M, et al. Effectiveness of Lactobacilluscontaining
vaginal tablets in the treatment of symptomatic
bacterial vaginosis. Clin Microbiol Infect 2009;15: 67-74.
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randomized, placebo-controlled study. Am J Obstet
Gynecol. 2010; 203(2):120.e1-6.
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Gomes BC, De Martinis EC, dkk. Improved cure of
bacterial vaginosis with single dose of tinidazole (2g),
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RC-14: a randomized, double-blind, placebo-controlled
trial. Can J Microbiol. 2009;55(2):133-8.
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administration of Lactobacillus rhamnosus following
conventional metronidazole therapy: how to lower the rate of
bacterial vaginosis recurrences. New Microbiol.
2008;31(3):429-33.
18. Marcone V, Rocca G, Lichtner M, Calzolari E. Long-term
vaginal administration of Lactobacillus rhamnosus as a
complementary approach to management of bacterial
vaginosis. Int J Gynaecol Obstet. 2010; 110(3): 223-6.
19. Larsson PG, Stray-Pedersen B, Ryttig KR, Larsen S.
Human lactobacilli as supplementation of clindamycin to
patients with bacterial vaginosis reduce the recurrence rate;
a 6-month, double blind, randomized, placebo-controlled
study. BMC Womens Health. 2008; 8(3): 1-8.
20. Reid G, Bruce AW, Fraser N, Heinemann C, Owen J,
Henning B. Oral probiotics can resolve urogenital
infections. FEMS Immun Med Microbiol 2001; 30: 49–52.
21. Martinez RC, Franceschini SA, Patta MC, Quintana SM,
Candido RC, dkk. Improved treatment of vulvovaginal
candidiasis with fluconazole plus probiotic Lactobacillus
rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett
Appl Microbiol. 2009; 49: 269-74.
22. Kovachef SM, Vatcheva-Dobrevska RS. Local probiotic
therapy for vaginal Candida albicans infections. Probiotics
Antimicrob Proteins. 2015;7(1):38-44.
23. Murina F, Graziottin A, Vicariotto F, De Seta F.
Can Lactobacillus fermentum LF10 and Lactobacillus
acidophilus LA02 in a slow-release vaginal product be useful
for prevention of recurrent vulvovaginal candidiasis?: a clinical
study. J Clin Gastroenterol. 2014; 48: S102-5.
2001-2004 National Health and Nutrition Examination
Survey data. Obset Gynecol. 2007; 109(1): 114-20.
2. Foxman B, Barlow R, D’Arcy H, Gillepsie B, Sobel JD.
Candida vaginitis: self reported incidence and associated costs.
Sex Transm Dis. 2000; 27: 230–5.
3. Ronnqvist D. Urogenital probiotics: potential role of
Lactobacillus in the prevention of urogenital infections in
women (dissertation). Umea University; 2007.
4. Parma M, Vanni VS, Bertini M, Candiani M. Probiotics in
the prevention of recurrences of bacterial vaginosis. Altern
Ther Health Med. 2014;20(1):52-7.
5. Mastromarino P, Vitali B, Mosca L. Bacterial vaginosis: a
review on clinical trial with probiotics. New Microbiol.
2013; 36:229-38.
MDVI Vol. 45. No. 2 Tahun 2018; 100–104
104
6. Kumar N, Behera B, Sagiri SS, Pal K, Ray SS, Roy S.
Bacterial vaginosis: etiology and modalities of treatment—a
brief note. J Pharm Bioallied Sci. 2011; 3(4): 496-503.
7. Hillier S, Marrazzo J, Holmes KK. Bacterial vaginosis. Dalam:
Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN,
Corey L, dkk, penyunting. Sexually transmited disease. Edisi
ke-4. New York: McGraw-Hill; 2008. h. 737-68.
8. Centers for Disease Control and Prevention. Sexually
transmitted diseases treatment guidelines. MMWR. 2010;
59: 56-63.
9. Mendling W, Brasch J. Guideline vulvovaginal candidosis
(2010) of the German Society for Gynecology and
Obstetrics, the working group for infections and
infectimmunology in gynecology and obstetrics, the
German Society of Dermatology, the Board of German
Dermatologists and the German Speaking Mycological
Society. Mycosis. 2012; 55(Suppl.3):1-13.
10. Liong MT. Safety of probiotics: translocation and infection.
Nutr Rev. 2008; 66: 192-202.
11. Falagas ME, Betsi GI, Athanasiou S. Probiotics for prevention
of recurrent vulvovaginal candidiasis: a review. J Antimicrob
Chemother. 2006; 58: 266-72.
12. Anukam KC, Osazuwa E, Osemene GI, Ehigiagbe F, Bruce
AW, Reid G. Clinical study comparing probiotic
Lactobacillus GR-1 and RC-14 with metronidazole vaginal
gel to treat symptomatic bacterial vaginosis. Microbes Infect.
2006; 8:2772-6.
13. Mastromarino P, Macchia S, Meggiorini L, Trinchieri V,
Mosca L, Perluigi M, et al. Effectiveness of Lactobacilluscontaining
vaginal tablets in the treatment of symptomatic
bacterial vaginosis. Clin Microbiol Infect 2009;15: 67-74.
14. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic
capsules for recurrent bacterial vaginosis: a double-blind,
randomized, placebo-controlled study. Am J Obstet
Gynecol. 2010; 203(2):120.e1-6.
15. Petricevic L, Witt A. The role of Lactobacillus casei
rhamnosus Lcr35 in restoring the normal vaginal flora after
antibiotic treatment of bacterial vaginosis. BJOG J Gy.
2008;115(11):1369-74.
16. Martinez RC, Franceschini SA, Patta MC, Quintana SM,
Gomes BC, De Martinis EC, dkk. Improved cure of
bacterial vaginosis with single dose of tinidazole (2g),
Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri
RC-14: a randomized, double-blind, placebo-controlled
trial. Can J Microbiol. 2009;55(2):133-8.
17. Marcone V, Calzolari E, Bertini M. Effectiveness of vaginal
administration of Lactobacillus rhamnosus following
conventional metronidazole therapy: how to lower the rate of
bacterial vaginosis recurrences. New Microbiol.
2008;31(3):429-33.
18. Marcone V, Rocca G, Lichtner M, Calzolari E. Long-term
vaginal administration of Lactobacillus rhamnosus as a
complementary approach to management of bacterial
vaginosis. Int J Gynaecol Obstet. 2010; 110(3): 223-6.
19. Larsson PG, Stray-Pedersen B, Ryttig KR, Larsen S.
Human lactobacilli as supplementation of clindamycin to
patients with bacterial vaginosis reduce the recurrence rate;
a 6-month, double blind, randomized, placebo-controlled
study. BMC Womens Health. 2008; 8(3): 1-8.
20. Reid G, Bruce AW, Fraser N, Heinemann C, Owen J,
Henning B. Oral probiotics can resolve urogenital
infections. FEMS Immun Med Microbiol 2001; 30: 49–52.
21. Martinez RC, Franceschini SA, Patta MC, Quintana SM,
Candido RC, dkk. Improved treatment of vulvovaginal
candidiasis with fluconazole plus probiotic Lactobacillus
rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett
Appl Microbiol. 2009; 49: 269-74.
22. Kovachef SM, Vatcheva-Dobrevska RS. Local probiotic
therapy for vaginal Candida albicans infections. Probiotics
Antimicrob Proteins. 2015;7(1):38-44.
23. Murina F, Graziottin A, Vicariotto F, De Seta F.
Can Lactobacillus fermentum LF10 and Lactobacillus
acidophilus LA02 in a slow-release vaginal product be useful
for prevention of recurrent vulvovaginal candidiasis?: a clinical
study. J Clin Gastroenterol. 2014; 48: S102-5.
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Published
2019-05-09
How to Cite
Wirantari, N., & Hidayati, A. N. (2019). Peran Lactobacillus Pada Managemen Infeksi Endogen Genitalia Wanita. Media Dermato-Venereologica Indonesiana, 45(2). https://doi.org/10.33820/mdvi.v45i2.22
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