MELASMA DALAM SUDUT PANDANG GENETIK
DOI:
https://doi.org/10.33820/mdvi.v46i3.75Abstract
Melasma merupakan kelainan hiperpigmentasi pada wajah dan terdistribusi secara simetris. Lebih
banyak terjadi pada wanita usia reproduktif dan banyak terjadi pada seseorang dengan tipe kulit III-V.
Melasma sering memberikan dampak negatif pada kualitas hidup pasien dalam hubungan sosial. Kelainan
ini sangat sulit diobati dan memerlukan biaya yang cukup mahal, namun sering tidak memuaskan baik
bagi pasien maupun dokter yang menanganinya. Patogenesis melasma bersifat multifaktor dan belum dapat
dijelaskan sepenuhnya. Faktor genetik, hormon, dan pajanan ultra-violet (UV) merupakan faktor risiko
melasma. Dari semua faktor tersebut diduga faktor genetik dan pajanan matahari berperan utama dalam
patogenesis melasma. Selain itu riwayat melasma dalam keluarga juga merupakan faktor risiko. Beberapa
penelitian terbaru menemukan beberapa ekspresi gen dan melibatkan beberapa jalur yang berperan dalam
patogenesis melasma. Gen melanocortin-1 receptor (MC1R) merupakan salah satu gen yang diduga berperan
secara genetik pada melasma.
Kata kunci: Melasma, genetik, hormonal, pajanan UV dan MC1-R
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References
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17. GarcÃa-Borrón JC, Sánchez-Laorden BL, Jiménez-Cervantes C. Melanocortin-1 receptor structure and functional regulation. Pigment Cell Res.2005; 18: 393–410.
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19. Abdel-Malek ZA, Knittel J, Kadekaro AL, Swope VB, Starner R. The Melanocortin 1 Receptor and the UV Response of Human Melanocytes— A Shift in Paradigma. Photochemestry Photobiology. 2008;84:501–8.
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21. Damevska Katerina. New aspect of melasma. Serbian Journal of Dermatology and Venereology.2014;6(1): 5-18.
22. Guarneri F. Etiopathogenesis of Melasma. Pigment. Disord. 2014;(S)1:1-5.
23. Kang WH, Yoon KH, Lee E.-S, Kim J, Lee KB, Yim H, Sohn S, Im S. Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol.2002;146:228–37.
24. Ortonne J, Arellano I, Berneburg M, Cestari T, Chan H, Grimes P, Hexsel D, ImS, Lim J, Lui H, Pandya A, Picardo M, Rendon M, Taylor S, Van Der Veen J, Westerhof W. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma. JEADV. 2009; 23:1254–62
25. Chatterjee M, Vasudevan B. Recent advances in melasma. Pigment Int.2014;1:70-80
26. Lee AY.An updated review of melasma pathogenesis. Dermatol. Sinica. 2014; 32:233–9.
27. Rathi S, Achar, A. Melasma: A clinico-epidemiological study of 312 cases. Indian J Dermatol. 2011; 56:380-2
28. Kumre K, Varma K, Sharma H, Singh U. Study of hormonal profile in female melasma patient in a tertiary care hospital. J Evol Med Dent Sci. 2016;5:1663–6.
29. Suryaningsih BE, Sobono H. Biologi Melanosit. Majalah Dermato-Veneorologi Indonesia 2016:43(2);78-82.
30. Suryaningsih BE, Polimorfisme Gen Reseptor Melanokortin 1 (MC1R) dan Gen Antagonis Interleukin 1 (IL-1RA) Pada Melasma, Studi Pada Populasi Wanita Suku Jawa di Yogyakarta [Disertasi]. Yogyakarta: Universitas Gadjah Mada; 2018.
2. Ritter CG, Fiss DVC, Borges da Costa JAT, de Carvalho RR, Bauermann G, Cestari TF. Extra-facial melasma: clinical, histopathological, and immunohistochemical case-control study. JEADV. 2013; 27:1088–94.
3. Handel AC, Miot LDB, Miot HA. Melasma: a clinical and epidemiological review. An Bras Dermatol. 2014;89:771–82.
4. Guinot C, Cheffai S, Latreille J, Dhaoui M, Youssef S., Jaber K, Nageotte O, Doss N. Aggravating factors for melasma: a prospective study in 197 Tunisian patients. JEADV. 2010;24:160-9.
5. Sonthalia S, Sarkar R. Etiopathogenesis of melasma. Pigment Int.2015;2:21-7.
6. Sarkar R, Arora P, Garg V.K, Sonthalia S, Gokhale N. Melasma update. Indian Dermatol. Online J.2014; 5: 426–35.
7. Tzouveka E. Epidemiology and risk factors of melasma..Journal of Pigmentary Disorder2014;1:1-3.
8. Videira IF dos S, Moura DFL, Magina S. Mechanisms regulating melanogenesis*. An Bras Dermatol. 2013;88:76–83.
9. Arora P, Garg V, Sonthalia S, Gokhale N, Sarkar R. Melasma update. Indian Dermatol. Online J 2014 ; 5: 426-9.
10. Carroll L, Voisey J, Van Daal A. Gene polymorphisms and their effects in the melanocortin system. Peptides 2005;26:1871–85.
11. Cichorek M, Wachulska M, Stasiewicz A, Tymińska A. Skin melanocytes: biology and development. Adv Dermatol Allergol. 2013;1:30–41.
12. Bolognia Jean L dan Orlow Seth JMelanocyte Biology. chapter 65.Dermatology. Edisi ke-3. Philadelphia: WB Saunders; 2012.h.1011-21. 13. Tsatmali M, Ancans J, Thody AJ. Melanocyte function and its control by melanocortin peptides. J. Histochem & Cytochem. 2002;50:125–33.
14. Schaffer Julie V dan Bolognia Jean L. The Biology of The Melanocyte: Cancer of the Skin. Edisi ke-2. New York: Saunders; 2011.h.23-38 .
15. Dessinioti C, Antoniou C, Katsambas A, Stratigos AJ. Melanocortin 1 Receptor Variants: Functional Role and Pigmentary Associations.Photochemestry and Photobiology.2011;87:978-87.
16. Switonski M, Mankowska M, Salamon S. Family of melanocortin receptor (MCR) genes inmammals--mutations, polymorphisms and phenotypic effects. J Appl Genet. 2013;54:461–72.
17. GarcÃa-Borrón JC, Sánchez-Laorden BL, Jiménez-Cervantes C. Melanocortin-1 receptor structure and functional regulation. Pigment Cell Res.2005; 18: 393–410.
18. Schallreuter KU. Advances in Melanocyte Basic Science Research. Dermatol Clin. 2007;25:283–91.
19. Abdel-Malek ZA, Knittel J, Kadekaro AL, Swope VB, Starner R. The Melanocortin 1 Receptor and the UV Response of Human Melanocytes— A Shift in Paradigma. Photochemestry Photobiology. 2008;84:501–8.
20. Baxter Laura L dan Pavan William J. The etiology and molecular genetics of human pigmentation disorder. Wiley Interdisciplenary Reviews Developmental Biology. 2013;2(3): 379-92.
21. Damevska Katerina. New aspect of melasma. Serbian Journal of Dermatology and Venereology.2014;6(1): 5-18.
22. Guarneri F. Etiopathogenesis of Melasma. Pigment. Disord. 2014;(S)1:1-5.
23. Kang WH, Yoon KH, Lee E.-S, Kim J, Lee KB, Yim H, Sohn S, Im S. Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol.2002;146:228–37.
24. Ortonne J, Arellano I, Berneburg M, Cestari T, Chan H, Grimes P, Hexsel D, ImS, Lim J, Lui H, Pandya A, Picardo M, Rendon M, Taylor S, Van Der Veen J, Westerhof W. A global survey of the role of ultraviolet radiation and hormonal influences in the development of melasma. JEADV. 2009; 23:1254–62
25. Chatterjee M, Vasudevan B. Recent advances in melasma. Pigment Int.2014;1:70-80
26. Lee AY.An updated review of melasma pathogenesis. Dermatol. Sinica. 2014; 32:233–9.
27. Rathi S, Achar, A. Melasma: A clinico-epidemiological study of 312 cases. Indian J Dermatol. 2011; 56:380-2
28. Kumre K, Varma K, Sharma H, Singh U. Study of hormonal profile in female melasma patient in a tertiary care hospital. J Evol Med Dent Sci. 2016;5:1663–6.
29. Suryaningsih BE, Sobono H. Biologi Melanosit. Majalah Dermato-Veneorologi Indonesia 2016:43(2);78-82.
30. Suryaningsih BE, Polimorfisme Gen Reseptor Melanokortin 1 (MC1R) dan Gen Antagonis Interleukin 1 (IL-1RA) Pada Melasma, Studi Pada Populasi Wanita Suku Jawa di Yogyakarta [Disertasi]. Yogyakarta: Universitas Gadjah Mada; 2018.
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Published
2019-09-09
How to Cite
Suryaningsih, B. E. (2019). MELASMA DALAM SUDUT PANDANG GENETIK. Media Dermato-Venereologica Indonesiana, 46(3). https://doi.org/10.33820/mdvi.v46i3.75
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