VITAMIN D TOPIKAL PADA PSORIASIS: SEBUAH TELAAH SISTEMATIK
DOI:
https://doi.org/10.33820/mdvi.v47i4.374Keywords:
vitamin d, topikal, psoriasisAbstract
First line therapy for mild to moderate plaque psoriasis is topical therapy. Topical corticosteroids are first line therapy for psoriasis, but it has many side effects. Topical vitamin D is an alternative sparing therapy topical corticosteroid for psoriasis. Purpose to review various studies on the effects of topical vitamin D monotherapy for psoriasis. Literature search through PubMed and Science direct for published articles within the past 10 years. Analysis follows inclusion and exclusion criterias. Articles are included if it reviews the effectivity of topical vitamin D as monotherapy for psoriatic lesions. Review includes 13 randomized controlled trials, involving 8.391 psoriasis patients. Clinical evidences show therapeutic effects of topical vitamin D for psoriasis. Ointment as vitamin D vehicles has better penetration. Effectivity of topical vitamin D as monotherapy is inferior when compared with combined therapy or corticosteroid combination. Long term monotherapy with topical vitamin D has minimum side effects.
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References
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2. Rosina P, Giovannini A, Gisondi P, Girolomoni G. Microcirculatory modifications of psoriatic lesions during topical therapy. Skin Res Technol. 2009;15:135-8.
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7. Lebwohl M, Ortonne JP, Andres P, Briantais P. Calcitriol Ointment 3μg/g Is Safe and Effective Over 52 Weeks for the Treatment of Mild to Moderate Plaque Psoriasis. Cutis. 2009;83:205-12
8. Kragballe K, Hoffmann V, Ortonne JP, Tan J, Nording P, Segaert S. Efficacy and safety of calcipotriol plus betamethasone dipropionate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trial. BJD. 2009;161:159–66.
9. Alora –palli MB, Perkins AC, Cott AV, Kimball AB. Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: a controlled comparison with calcipotriene (calcipotriol) cream. Am J Clin Dermatol. 2010;11(4):275-83.
10. Fleming C, Ganslandt C, Guenthe L. Calcipotriol plus betame- thasone dipropionate gel compared with its active components in the same vehicle and the vehicle alone in the treatment of psoriasis vulgaris: a randomised, parallel group, double-blind, exploratory study. Eur J Dermatol 2010;20(4):465-71.
11. Van der velden HMJ, Pasch MC, Van Erp PJ. Treatment of plaque psoriasis with the two-compound product calcipotriol/ betamethasone dipropionate versus both monotherapies: An immunohistochemical study. J Dermatolog Treat. 2010;21:13–22.
12. Queille-roussel C, Hoffmann V, Ganslandt C, Hansen KK. Comparison of the antipsoriatic effect and tolerability of calcipotriol-containing products in the treatment of psoriasis vulgaris using a modified psoriasis plaque test. Clin Drug Investig. 2012;1:1-3.
13. Singh P, Gupta S, Abidi A, Krishna A. Comparative evaluation of topical calsipotriol vs coal tar and salicylic acid ointment in chronic plague psoriasis. J Drugs Dermatol. 2013;12(8):868-73.
14. Takahashi H, Tsuji H, Yamamoto A, Iizuka H. Comparison of clinical effects of psoriasis treatment regimens among calcipotriol alone, narrowband ultraviolet B phototherapy alone, combination of calcipotriol and narrowband ultraviolet B phototherapy once a week, and combination of calcipotriol and narrowband ultraviolet B phototherapy more than twice a week. J Dermatol. 2013;40:424-27.
15. Ma L, Yang Q, Yang H, Wang G, Zheng M, Hao F, dkk. Calci- potriol plus betamethasone dipropionate gel compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized, controlled trial investigating efficacy and safety in a Chinese population. Int J Dermatol. 2016;55:106–13.
16. Golusin Z, Jovanović M, Magda N, Stojanović S, Matić M, Petrović A. Effects of Rusanda Spa balneotherapy combined with calcipotriol on plaque psoriasis. Vojnosanit Pregl. 2015;72(11):1010-7.
17. Rafalovich N. The Effect of Vitamin D Supplementation on Atopic Dermatitis. School of Physician Assistant Studies. 2015;511:1-21
18. Rizova E, Corroller M. Topical calcitriol studies on local tolerance and systemic safety. Br J Dermatol. 2001;144(suppl 58):3-10.
2. Rosina P, Giovannini A, Gisondi P, Girolomoni G. Microcirculatory modifications of psoriatic lesions during topical therapy. Skin Res Technol. 2009;15:135-8.
3. Mason A, Mason J, Cork M, Hancock H, Dooley G. Topical treatment for chronic plague psoriasis: An abridged Cochrane systematic review. JAAD. 2013;1:799-807.
4. WenZ,XuanML,YanY,LiXY,YaoDN,LiG,dkk. Chinese medicine combined with calcipotriol betamethasone and calcipotriol ointment for psoriasis vulgaris (CMCBCOP): study protocol for a randomized controlled trial. TRIALS. 2014;15:294-8.
5. Feldman SR, Matheson R, Bruce S, Grande K, Markowitz O, Kempers S, dkk. Efficacy and safety of calcipotriene 0.005% foam for the treatment of plaque-type psoriasis: results of two multicenter, randomized, double-blind, vehicle-controlled, phase III clinical trials. Am J Clin Dermatol. 2012;13(4):261-71.
6. Levine D, Even –chen Z, Lipets I, Pritulo OA, Svyatenco TV, Andrashko Y, dkk. Pilot, multicenter, double-blind, randomized placebo-controlled bilateral comparative study of a combination of calcipotriene and nicotinamide for the treatment of psoriasis. JAAD. 2010;1:775-81.
7. Lebwohl M, Ortonne JP, Andres P, Briantais P. Calcitriol Ointment 3μg/g Is Safe and Effective Over 52 Weeks for the Treatment of Mild to Moderate Plaque Psoriasis. Cutis. 2009;83:205-12
8. Kragballe K, Hoffmann V, Ortonne JP, Tan J, Nording P, Segaert S. Efficacy and safety of calcipotriol plus betamethasone dipropionate scalp formulation compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized controlled trial. BJD. 2009;161:159–66.
9. Alora –palli MB, Perkins AC, Cott AV, Kimball AB. Efficacy and tolerability of a cosmetically acceptable coal tar solution in the treatment of moderate plaque psoriasis: a controlled comparison with calcipotriene (calcipotriol) cream. Am J Clin Dermatol. 2010;11(4):275-83.
10. Fleming C, Ganslandt C, Guenthe L. Calcipotriol plus betame- thasone dipropionate gel compared with its active components in the same vehicle and the vehicle alone in the treatment of psoriasis vulgaris: a randomised, parallel group, double-blind, exploratory study. Eur J Dermatol 2010;20(4):465-71.
11. Van der velden HMJ, Pasch MC, Van Erp PJ. Treatment of plaque psoriasis with the two-compound product calcipotriol/ betamethasone dipropionate versus both monotherapies: An immunohistochemical study. J Dermatolog Treat. 2010;21:13–22.
12. Queille-roussel C, Hoffmann V, Ganslandt C, Hansen KK. Comparison of the antipsoriatic effect and tolerability of calcipotriol-containing products in the treatment of psoriasis vulgaris using a modified psoriasis plaque test. Clin Drug Investig. 2012;1:1-3.
13. Singh P, Gupta S, Abidi A, Krishna A. Comparative evaluation of topical calsipotriol vs coal tar and salicylic acid ointment in chronic plague psoriasis. J Drugs Dermatol. 2013;12(8):868-73.
14. Takahashi H, Tsuji H, Yamamoto A, Iizuka H. Comparison of clinical effects of psoriasis treatment regimens among calcipotriol alone, narrowband ultraviolet B phototherapy alone, combination of calcipotriol and narrowband ultraviolet B phototherapy once a week, and combination of calcipotriol and narrowband ultraviolet B phototherapy more than twice a week. J Dermatol. 2013;40:424-27.
15. Ma L, Yang Q, Yang H, Wang G, Zheng M, Hao F, dkk. Calci- potriol plus betamethasone dipropionate gel compared with calcipotriol scalp solution in the treatment of scalp psoriasis: a randomized, controlled trial investigating efficacy and safety in a Chinese population. Int J Dermatol. 2016;55:106–13.
16. Golusin Z, Jovanović M, Magda N, Stojanović S, Matić M, Petrović A. Effects of Rusanda Spa balneotherapy combined with calcipotriol on plaque psoriasis. Vojnosanit Pregl. 2015;72(11):1010-7.
17. Rafalovich N. The Effect of Vitamin D Supplementation on Atopic Dermatitis. School of Physician Assistant Studies. 2015;511:1-21
18. Rizova E, Corroller M. Topical calcitriol studies on local tolerance and systemic safety. Br J Dermatol. 2001;144(suppl 58):3-10.
Published
2022-07-12
How to Cite
Kusumaningrum, N., & Febriana, S. A. (2022). VITAMIN D TOPIKAL PADA PSORIASIS: SEBUAH TELAAH SISTEMATIK. Media Dermato-Venereologica Indonesiana, 47(4), 216–222. https://doi.org/10.33820/mdvi.v47i4.374
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Tinjauan Pustaka
