Pemberian Suplementasi Probiotik Pada Kehamilan Untuk Pencegahan Dermatitis Atopik Pada Anak
DOI:
https://doi.org/10.33820/mdvi.v45i3.31Abstract
Dermatitis atopik adalah penyakit inflamasi kronis dengan prevalensi tinggi pada anak yang terus meningkat di seluruh dunia. Dermatitis atopik merupakan penyakit multifaktor yang mencakup faktor genetik, pajanan infeksi, pajanan makanan, alergen dan lingkungan. Pruritus berulang yang dialami oleh pasien dermatitis atopik dapat menurunkan kualitas hidup dan dapat menjadi masalah yang serius. Hingga saat ini steroid masih menjadi terapi utama bagi pasien dermatitis atopik, baik pada anak maupun dewasa. Namun mengingat banyaknya efek samping yang ditimbulkan akibat pemberian steroid jangka panjang, alternatif terapi lain terus dicari. Peningkatan insidens dermatitis atopik yang bermakna secara global telah mengubah fokus riset para peneliti dalam pencegahan dan penanganan dermatitis atopik. Salah satu upaya pencegahan dermatitis atopik pada anak yang dianggap menjanjikan adalah pemberian suplementasi probiotik pada masa kehamilan. Beberapa penelitian memberikan hasil yang positif dalam menurunkan risiko dermatitis atopik melalui pemberian suplementasi probiotik saat hamil. Namun berbagai faktor, misalnya jenis probiotik yang digunakan, waktu pemberian, durasi pajanan probiotik dan dosis pemberian juga penting untuk diteliti lebih lanjut. Â
Kata kunci: probiotik, dermatitis atopik, pencegahan, alergi
Downloads
Download data is not yet available.
References
1. Yesilova Y, Calka O, Akdeniz N, Berktas M. Effect of probiotics on the treatment of children with atopic dermatitis. Ann Dermatol. 2012; 24: 189-93.
2. Rather I, Bajpail V, Kumar S, Lim J, Paek W, Park Y. Probiotics and atopic dermatitis: an overview. Front Microbiol. 2016; 7: 130-41.
3. Barthow C, Wickens K, Stanley T, Mitchell E, Maude R, Abels P, dkk. The probiotics in pregnancy study (PiP study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy. BMC Preg Chil. 2016; 16:133.
4. Kim M, Kim J, Yoon Y, Seo J, Chung M, Yum D. A probiotic preparation alleviates atopic dermatitis-like skin lesions in murine models. Toxicol Res. 2016; 32:149–58.
5. Allen S, Jordan S, Storey M, Thornton C, Gravenor M, Garaiova I, dkk. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014; 99:1014-9.
6. Halim A, Munasir Z, Rohsiswatno R. Manfaat pemberian ASI eksklusif dalam pencegahan kejadian dermatitis atopik pada anak. Sari pediatri. 2014; 15: 345-52.
7. Notoatmojo H, Wistiani. Hubungan pajanan alergen terhadap kejadian alergi pada anak. Sari pediatri. 2011; 13: 185-90.
8. Doege K, Grajecki D, Zyriax B, Detinkina E, Eulenburg C, Buhling K. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood – a meta analysis. Br J Nutr. 2012; 107: 1-6.
9. Rather IA, Bajpal VK, Kumar S, Lim J, Paek WK, Park YH. Probiotics and Atopic Dermatitis: An Overview. Front Microbiol. 2016;7:507.
10. Meneghin F, Fabiano V, Mameli C, Zuccotti GV. Probiotics and Atopic Dermatitis in Children. J Pharm. 2012;5:727-44.
11. Kim MS, Kim JE, Yoon YS, Kim TH, Seo JG, Chung MJ, dkk. A Probiotic Preparation Alleviates Atopic Dermatitis-Like Skin Lesions in Murine Models. Toxicol Res. 2016;32;149-58
12. Weston S, Halbert A, Richmond P, Prescott SL. Effect of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child. 2005;90:892–7.
13. Ji GE, Kim NY. Effects of probiotics on the prevention of atopic dermatitis. Korean J Pediatr. 2012;55:193-201
14. Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu C, Buhling KJ. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood – a meta-analysis. Br J Nutr. 2012;107:1–6
15. Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, Garaiova I, dkk. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014; 99:1014-9.
16. Cabana, M. Early Probiotic Supplementation for the Prevention of Atopic Disease in Newborns—Probiotics and the Hygiene Hypothesis. Bio Micro. 2011;30:129–33
17. Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, dkk. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organ J. 2015;8:1–13.
18. Lyons JJ, Milner JD, Stone KD. Atopic Dermatitis in Children: Clinical Features, Pathophysiology and Treatment. Immunol Allergy Clin North Am. 2015;35:161–83.
19. Thomsen SF. Atopic Dermatitis: Natural History, Diagnosis, and Treatment. ISRN Allergy. 2014, Article ID 354250
20. Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. BioMed Res Int. 2016; 49:740-4.
21. Son JH, Chung BY, Kim HO, Park CW. Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset. J Korean Med Sci. 2017;32:1360-6.
22. Kanwar AJ, Dipankar D. Epidemiology and Clinical Features of Atopic Dermatitis in India. Indian J Dermatol. 2011;56:471-5.
23. Werfel T, Schwerk N, Hansen G, Kapp A. The Diagnosis and Graded Therapy of Atopic Dermatitis. Dtsc Arztebl Int. 2014;111:509-20.
24. Werfel T, Heratizadeh A, Werner A, Ahrens F, Augustin M, Biedermann T, dkk. S2k Guideline on Diagnosis and Treatment of Atopic Dermatitis – Short Version. Allergo J Int. 2016;25:82-95.
25. Siegfried EC, Hebert AA. Diagnosis of atopic dermatitis: Mimics, Overlaps, and Complications. J Clin Med. 2015;4:884-917.
26. Bieber T. Atopic Dermatitis. Ann Dermatol. 2010;22:125-37.
27. Boediardja SA. Dermatitis Atopik. Dalam : Menaldi SLSW, Bramono K, Indriatmi W, penyunting. Ilmu Penyakit Kulit dan Kelamin. Edisi ke-7. Jakarta:Badan Penerbit FKUI;2015.h.167-83.
28. Elazab N, Mendy A, Gasana J, Vieira E, Quizon A, Forno E. Probiotic Administration in Early Life, Atopy, and Asthma : A Meta-Analysis of Clinical Trials. J Pediatr. 20013;132:e666-e76.
29. Dotterud CK, Storrø O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: A randomized, double-blind trial. Br. J. Dermatol. 2010; 163:616–23.
30. Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L. Probiotics Supplementation During Pregnancy or Infancy: A meta-analysis. Epidemiol. 2012;23: 402–14.
2. Rather I, Bajpail V, Kumar S, Lim J, Paek W, Park Y. Probiotics and atopic dermatitis: an overview. Front Microbiol. 2016; 7: 130-41.
3. Barthow C, Wickens K, Stanley T, Mitchell E, Maude R, Abels P, dkk. The probiotics in pregnancy study (PiP study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy. BMC Preg Chil. 2016; 16:133.
4. Kim M, Kim J, Yoon Y, Seo J, Chung M, Yum D. A probiotic preparation alleviates atopic dermatitis-like skin lesions in murine models. Toxicol Res. 2016; 32:149–58.
5. Allen S, Jordan S, Storey M, Thornton C, Gravenor M, Garaiova I, dkk. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014; 99:1014-9.
6. Halim A, Munasir Z, Rohsiswatno R. Manfaat pemberian ASI eksklusif dalam pencegahan kejadian dermatitis atopik pada anak. Sari pediatri. 2014; 15: 345-52.
7. Notoatmojo H, Wistiani. Hubungan pajanan alergen terhadap kejadian alergi pada anak. Sari pediatri. 2011; 13: 185-90.
8. Doege K, Grajecki D, Zyriax B, Detinkina E, Eulenburg C, Buhling K. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood – a meta analysis. Br J Nutr. 2012; 107: 1-6.
9. Rather IA, Bajpal VK, Kumar S, Lim J, Paek WK, Park YH. Probiotics and Atopic Dermatitis: An Overview. Front Microbiol. 2016;7:507.
10. Meneghin F, Fabiano V, Mameli C, Zuccotti GV. Probiotics and Atopic Dermatitis in Children. J Pharm. 2012;5:727-44.
11. Kim MS, Kim JE, Yoon YS, Kim TH, Seo JG, Chung MJ, dkk. A Probiotic Preparation Alleviates Atopic Dermatitis-Like Skin Lesions in Murine Models. Toxicol Res. 2016;32;149-58
12. Weston S, Halbert A, Richmond P, Prescott SL. Effect of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child. 2005;90:892–7.
13. Ji GE, Kim NY. Effects of probiotics on the prevention of atopic dermatitis. Korean J Pediatr. 2012;55:193-201
14. Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu C, Buhling KJ. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood – a meta-analysis. Br J Nutr. 2012;107:1–6
15. Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, Garaiova I, dkk. Probiotics in the prevention of eczema: a randomised controlled trial. Arch Dis Child. 2014; 99:1014-9.
16. Cabana, M. Early Probiotic Supplementation for the Prevention of Atopic Disease in Newborns—Probiotics and the Hygiene Hypothesis. Bio Micro. 2011;30:129–33
17. Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, dkk. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organ J. 2015;8:1–13.
18. Lyons JJ, Milner JD, Stone KD. Atopic Dermatitis in Children: Clinical Features, Pathophysiology and Treatment. Immunol Allergy Clin North Am. 2015;35:161–83.
19. Thomsen SF. Atopic Dermatitis: Natural History, Diagnosis, and Treatment. ISRN Allergy. 2014, Article ID 354250
20. Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. BioMed Res Int. 2016; 49:740-4.
21. Son JH, Chung BY, Kim HO, Park CW. Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset. J Korean Med Sci. 2017;32:1360-6.
22. Kanwar AJ, Dipankar D. Epidemiology and Clinical Features of Atopic Dermatitis in India. Indian J Dermatol. 2011;56:471-5.
23. Werfel T, Schwerk N, Hansen G, Kapp A. The Diagnosis and Graded Therapy of Atopic Dermatitis. Dtsc Arztebl Int. 2014;111:509-20.
24. Werfel T, Heratizadeh A, Werner A, Ahrens F, Augustin M, Biedermann T, dkk. S2k Guideline on Diagnosis and Treatment of Atopic Dermatitis – Short Version. Allergo J Int. 2016;25:82-95.
25. Siegfried EC, Hebert AA. Diagnosis of atopic dermatitis: Mimics, Overlaps, and Complications. J Clin Med. 2015;4:884-917.
26. Bieber T. Atopic Dermatitis. Ann Dermatol. 2010;22:125-37.
27. Boediardja SA. Dermatitis Atopik. Dalam : Menaldi SLSW, Bramono K, Indriatmi W, penyunting. Ilmu Penyakit Kulit dan Kelamin. Edisi ke-7. Jakarta:Badan Penerbit FKUI;2015.h.167-83.
28. Elazab N, Mendy A, Gasana J, Vieira E, Quizon A, Forno E. Probiotic Administration in Early Life, Atopy, and Asthma : A Meta-Analysis of Clinical Trials. J Pediatr. 20013;132:e666-e76.
29. Dotterud CK, Storrø O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: A randomized, double-blind trial. Br. J. Dermatol. 2010; 163:616–23.
30. Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L. Probiotics Supplementation During Pregnancy or Infancy: A meta-analysis. Epidemiol. 2012;23: 402–14.
Downloads
Published
2019-05-09
How to Cite
Octavia, N., Wiradarma, K., Inderawati, D. M., & Nasser, M. (2019). Pemberian Suplementasi Probiotik Pada Kehamilan Untuk Pencegahan Dermatitis Atopik Pada Anak. Media Dermato-Venereologica Indonesiana, 45(3). https://doi.org/10.33820/mdvi.v45i3.31
Issue
Section
Artikel Asli
