DIAGNOSIS DAN TATA LAKSANA NEVUS HORI
DOI:
https://doi.org/10.33820/mdvi.v49i4.284Keywords:
Nevus Hori, acquired circumscribed dermal melanositosis, diagnosis, tata laksana, acquired bilateral nevus of Ota like maculesAbstract
Nevus Hori (NH) merupakan hipermelanosis dermal didapat yang ditandai bercak coklat keabuan. NH bermanifestasi terutama di daerah fasial seperti zigomatikum, dahi, pelipis, kelopak mata dan pangkal hidung, tetapi dapat juga di ekstra fasial. NH memengaruhi kualitas hidup penderitanya karena dapat menganggu penampilan. Awitan NH bervariasi, dapat terjadi antara usia 12-72 tahun. Genetik memegang peran penting dalam patofisiologi NH. Beberapa faktor pencetus yang telah diidentifikasi terkait NH antara lain, inflamasi, radiasi ultraviolet, kehamilan, kontrasepsi, dan kosmetik. Manifestasi klinis NH sering menyerupai kelainan hiperpigmentasi dermal lain seperti melasma, nevus Ota, dan melanosis Riehl, sehingga masih sering terjadi kesalalahan diagnosis. Penegakan diagnosis dilakukan dengan mempertimbangkan manifestasi klinis pasien. Pemeriksaan penunjang tidak rutin dilakukan pada kasus NH. Bila diperlukan, pemeriksaan baku emas berupa pemeriksaan histopatologi dapat dilakukan. Tata laksana NH memiliki tantangan tersendiri. Tata laksana NH yang utama adalah menghindari tersediri. Tata laksana defenitif untuk kasus MH dilakukan dengan terapi kombinasi, baik terapi farmakologis dan non-farmakologis. Pilihan terapi yang dapat digunakan adalah terapi topikal, dan tindakan invasif seperti dermabrasi, krioterapi dan laser.
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References
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26. Tian BWCA. Novel treatment of Hori’s nevus: A combination of fractional nonablative 2,940-nm Er:YAG and low-fluence 1,064-nm Q-switched Nd:YAG laser. J Cutan Aesthet Surg. 2015;8(4):227–9.
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28. Kaur H, Sarma P, Kaur S, Kaur H, Prajapat M, Mahendiratta S, et al. Therapeutic options for management of Hori’s nevus: a systematic review. Dermatol Ther. 2020;33(1):1–10.
29. Zeng R, Liu Y-Z, Lin T, Guo L-F, Ge Y-P, Zhang M-L, et al. Effects of Q-switched laser treatments on acquired bilat- eral nevus of Ota-like macules. Int J Dermatology Venereol. 2019;2(2):70–6.
30. Tay Y-K. Treatment of pigmented lesions in the Asian skin. In: Tay Y-K, editor. Textbook of Laser and Light Dermatology in the Asian Skin. United Kingdom: World Scientific; 2011. p. 37–51.
2. Zhang Q, Jiang P, Tan C, Yang G. Clinical profile and trigger- ing factors for acquired, bilateral nevus of Ota-like macules. Cutan Ocul Toxicol. 2017;36(4):327–30.
3. Lu Q, Yang C, Wu J, Wei Z, Xu S, Wang C, et al. Confocal laser scanning microscopy, a diagnostic alternative for five pigmented lesions on the face: an observational study. Ski Res Technol. 2019;25(6):871–6.
4. Bhat RM, Pinto HP, Dandekeri S, Ambil SM. Acquired bi- lateral nevus of ota-like macules with Mucosal involve- ment: A new variant of Hori’s nevus. Indian J Dermatol. 2014;59(3):293–6.
5. Zhong Y, Huang L, Yan T, Chen Y, Yang B, Man MQ. Both age and disease duration are associated with clinical pheno- type of hori’s nevus in chinese: A retrospective analysis of
497 cases. Clin Cosmet Investig Dermatol. 2021;14:65–71. 6. Ando H, Yoshimoto S, Yoshida M, Shimoda N, Tadokoro R, Kohda H, et al. Dermal fibroblasts internalize phosphatidyl- serine-exposed secretory melanosome clusters and apoptotic
melanocytes. Int J Mol Sci. 2020;21(16):1–14.
7. Lee JY, Kim EH, Kim KH, Kang HY, Lee ES, Kim YC. Ac- quired bilateral nevus of Ota-like macules: an immunohisto- logical analysis of dermal melanogenic paracrine cytokine
networks. Br J Dermatol. 2011;164(3):580–5.
8. Murakami F, Soma Y, Mizoguchi M. Acquired symmetrical dermal melanocytosis (nevus of Hori) developing after aggra-
vated atopic dermatitis. Br J Dermatol. 2005;152(5):903–8. 9. Li PH, Liu LH, Chang CC, Gao R, Leung CH, Ma DL, et al. Silencing stem cell factor gene in fibroblasts to regulate paracrine factor productions and enhance c-Kit expression in
melanocytes on melanogenesis. Int J Mol Sci. 2018;19(5). 10. Lee JY, Lee JS, Kim YC. Histopathological features of acquired dermal melanocytosis. Eur J Dermatol. 2010;20(3):345–8. 11. Park JM, Tsao H, Tsao S. Acquired bilateral nevus of Ota- like macules (Hori nevus): etiologic and therapeutic consid-
22. Kagami S, Asahina A, Watanabe R, Mimura Y, Shirai A, Hattori N, et al. Treatment of 153 Japanese patients with Q- switched alexandrite laser. Lasers Med Sci. 2007;22(3):159–
erations. J Am Acad Dermatol. 2009;61(1):88–93. 63.
12. Ee HL, Wong HC, Goh CL, Ang P. Characteristics of Hori ne- vus: a prospective analysis. Br J Dermatol. 2006;154(1):50–3.
13. Lee B, Kim Y, Kang W, Al. E. Comparison of characteris- tics of acquired bilateral nevus of Ota-like macules and ne- vus Ota according to therapeutic outcome. J Korean Med Sci.
23. Agustine R, Yenn SW. Penggunaan Laser Pada Lesi Hiperpig- mentasi. MDVI. 2011;38(2):96–103.
24. Lee WJ, Han SS, Chang SE, Lee MW, Choi JH, Moon KC, et al. Q-switched ND:YAG laser therapy of acquired bilateral nevus of Ota-like macules. Ann Dermatol. 2009;21(3):255–
2004;19:554–9. 60.
14. Elder DE, Elenitsas R, Rosenbach M, Murphy GF, Rubin AI, Xu X. Lever’s Histopathology of The Skin. Eleventh. Phila- delphia: Wolters Kluwer; 2015.
15. Long TF, Liu L, He L, Shen L Da, Gu H, Yang Z, et al. An- drogen, estrogen and progesterone receptors in acquired bilat- eral nevus of Ota-like macules. Pigment Cell Melanoma Res. 2010;23(1):144–6.
16. Bhattar PA, Zawar VP, Godse K V, Patil SP, Nadkarni NJ, Gautam MM. Exogenous ochronosis. Indian J Dermatol. 2015;60(6):537–43.
17. Indonesia KSDK dan PDSKK dan K. Pedoman Diagnosis dan Tata Laksana Melasma di Indonesia. Wasitaadmaja SM, Norawati L, editors. Indonesia: Fakultas Kedokteran Univer- sitas Indonesia; 2018.
18. Hale J, Dorton D, Kooi K Van Der. Acquired bilateral nevus of Ota-like macules (Hori’s nevus): a case report and treat- ment update. J Am Acad Dermatol. 2015;72(5):AB218.
19. Rahayu T, Putra E, Endy M, Diana R, Mochtar M. Prosedur dermabrasi di bidang dermatologi. Cermin Dunia Kedokt 286. 2020;47(5):387–94.
20. Kunachak S, Kunachakr S, Sirikulchayanonta V, Leelaudom- niti P. Dermabrasion is an effective treatment for acquired bilateral nevus of Ota-like macules. Vol. 22, Dermatologic Surgery. 1996. p. 559–62.
21. Akarsu S, Kamberoglu I. Cryotherapy for common prema- lignant and malignant skin disorders. Dermatol Surg Proced. 2017;
25. Lam AYM, Wong DSY, Lam LK, Ho WS, Chan HHL. A retrospective study on the efficacy and complications of Q-switched alexandrite laser in the treatment of acquired bilateral nevus of Ota-like macules. Dermatologic Surg. 2001;27(11):937–42.
26. Tian BWCA. Novel treatment of Hori’s nevus: A combination of fractional nonablative 2,940-nm Er:YAG and low-fluence 1,064-nm Q-switched Nd:YAG laser. J Cutan Aesthet Surg. 2015;8(4):227–9.
27. Modena D, Miranda A, Grecco C, Liebano R, Cordeiro R, Guidi R. Efficacy, safety, and guidelines of application of the fractional ablative laser erbium YAG 2940 nm and non-abla- tive laser erbium glass in rejuvenation, skin spots, and acne in different skin phototypes: a systematic review. Lasers Med Sci. 2020 Dec;35.
28. Kaur H, Sarma P, Kaur S, Kaur H, Prajapat M, Mahendiratta S, et al. Therapeutic options for management of Hori’s nevus: a systematic review. Dermatol Ther. 2020;33(1):1–10.
29. Zeng R, Liu Y-Z, Lin T, Guo L-F, Ge Y-P, Zhang M-L, et al. Effects of Q-switched laser treatments on acquired bilat- eral nevus of Ota-like macules. Int J Dermatology Venereol. 2019;2(2):70–6.
30. Tay Y-K. Treatment of pigmented lesions in the Asian skin. In: Tay Y-K, editor. Textbook of Laser and Light Dermatology in the Asian Skin. United Kingdom: World Scientific; 2011. p. 37–51.
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Published
2023-05-27
How to Cite
Diba, S., Antonius, C. S., Kurniawati, Y., Kartowigno, S., & Budiamal, S. (2023). DIAGNOSIS DAN TATA LAKSANA NEVUS HORI. Media Dermato-Venereologica Indonesiana, 49(4), 212–219. https://doi.org/10.33820/mdvi.v49i4.284
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