Peptida Antimikrobial

Authors

  • Hendra Gunawan Departemen IK Kulit dan Kelamin RSUP dr. Hasan Sadikin, Bandung
  • RM Rendy Ariezal Effendi

DOI:

https://doi.org/10.33820/mdvi.v45i1.18

Abstract

     Peptida antimikrobial (PAM) merupakan kelompok peptida di permukaan sel epitel yang bersifat mikrobisidal  dan sitolitik. Peptida ini berperan dalam respons imun bawaan,  sebagai lini pertama dalam pertahanan terhadap infeksi dengan cara membunuh langsung bakteri, jamur, atau virus. Dua kelompok besar PAM yang terdapat pada manusia yaitu defensin dan katelisidin. Defensin diklasifikasikan menjadi tiga tipe yaitu alfa, beta, dan teta defensin. Pada manusia, hanya terdapat satu tipe katelisidin yaitu human cathelicidin antimicrobial protein 18 (hCAP18), dengan LL-37 sebagai bentuk aktifnya. Tipe PAM lainnya pada manusia yaitu psoriasin, RNase 7, dan dermsidin. Mekanisme kerja PAM yaitu berikatan dengan membran sel mikroba dan membentuk sebuah celah, sehingga terjadi perubahan permeabilitas membran yang mengakibatkan sel mengalami lisis. Jumlah PAM akan meningkat saat terjadi infeksi dan inflamasi. Perubahan pola ekspresi PAM terdapat pada beberapa penyakit kulit yang mengalami inflamasi kronik misalnya psoriasis, dermatitis atopik, rosasea, akne vulgaris, hidradenitis supuratif, infeksi virus, dan lupus eritematosus sistemik. Hingga sat ini terus dikembangkan penelitian terhadap peranan PAM dalam bidang dermatologi. Beberapa jenis PAM yang saat ini tersedia di pasaran antara lain Plectasin®, Magainins®, Pexiganan®.

 

Kata kunci: defensin, katelidisin, peptida antimikrobial

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References

1. Pasupuleti M. Structural, functional and evolutionary studies of antimicrobial peptides. Doctoral dissertation. Lund: Lund Faculty of Medicine; 2009. h. 8-14.
2. Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther. 2004;4:543-9.
3. Izadpanah A, Gallo RL. Antimicrobial peptides. J Am Acad Dermatol. 2005;52:381-8.
4. Kenshi Y, Gallo RL. Antimicrobial peptides in human skin disease. Eur J Dermatol. 2008;18:11-21.
5. Schauber J, Gallo RL. Expanding the roles of antimicrobial peptides in skin: Alarming and arming keratinocytes. J Invest Dermatol. 2007;127:510-2.
6. Ganz T. Defensins: Antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003;3:710-20.
7. Modlin RL, Miller LS, Bangert C, Stingl G. Innate and adaptive immunity in the skin. Dalam: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, penyunting. Fitzpatrick’s dermatology in general medicine. Edisi ke-8. New York: Mc-Graw Hill; 2012. h. 107-8.
8. Gallo RL, Huttner KM. Antimicrobial peptides: An emerging concept in cutaneous biology. J Invest Dermatol. 1998;111:739-43.
9. Vargues T. Antimicrobial peptides - structure, function and resistance. Doctoral dissertation. Edinburgh: University of Edinburgh; 2009. h. 2-20.
10. Andersson ML, Karlsson JMT. CRS-Peptides: Unique defense peptide of mouse Paneth cell. Mucosal Immunol. 2012;5:367-76.
11. Schwarz T. Immunology. Dalam: Bolognia JL, Jorizzo JL, Rapini RP, penyunting. Dermatology. Edisi ke-2. New York: Mosby; 2008. h. 63-77.
12. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;425:389-94.
13. Gambichler T, Kobus S, Tigges C, Scola N, Altmeyer P, Kreuter A, dkk. Expression of antimicrobial peptides and proteins in etanercept - treated psoriasis patients. Reg Pept. 2011;167:163-6.
14. Gudjonsson JE, Elder JT. Psoriasis. Dalam: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, penyunting. Fitzpatrick’s dermatology in general medicine. Edisi ke-8. New York: Mc-Graw Hill; 2012. h. 197-231.
15. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem. 2001;276:5707-13.
16. Ong YP, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, dkk. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Eng J Med. 2002;347:1151-60.
17. Harder J, Bartels J, Christophers E, Schroder JM. A peptide antibiotic from human skin. Nature. 1997;387:861.
18. Buchau AS, Gallo RL. Innate immunity and antimicrobial defense systems in psoriasis. Clin Dermatol. 2007;25:616-24.
19. Peric M, Koglin S, Dombrowski Y, Grob K, Bradac E, Buchau A, dkk. Vitamin D analogs differentially control antimicrobial peptide/”alarmin” expression in psoriasis. PloS ONE. 2009;4(7):755-60.
20. Kim BJ, Rho YK, Lee HI, Jeong MS, Li K, Seo SJ, dkk. The effect of calcipotriol on the expression of human beta defensin-2 an LL-37 in cultured human keratinocytes. Clin Dev Immunol. 2009:645:89-7.
21. Jinquan T, Vorum H, Larsen CG, Madsen P, Rasmussen HH, Gesser B, dkk. Psoriasin-a novel chemotactic protein. J Invest Dermatol. 1996;107:5-10.
22. Rieg S, Steffen H, Seeber S, Humeny A, Kalbacher H, Dietz K, dkk. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis corelates with an impaired innate defense of human skin in vivo. J Immunol. 2005;174:8003-10.
23. Hofmann SC, Saborowski V, Lange S, Kern WV, Rieg S. Expression of innate defense antimicrobial peptides in hidradenitis supurativa. J Am Acad Dermatol. 2011;66:6.
24. Aoki W, Kuroda K, Ueda M. Next generation of antimicrobial peptides as molecular targeted medicines. J Biosci Bioeng. 2012;114:365-70.
25. Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Raventos S, Buskov S, dkk. Plectasin is a peptide antibiotic with therapeutic potential from a Saprophytic Fungus. Nature. 2005;437:975-80.
26. Zasloff M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Nat Acad Sci. 1987;84:5449-53.

Published

2019-05-09

How to Cite

Gunawan, H., & Effendi, R. R. A. (2019). Peptida Antimikrobial. Media Dermato-Venereologica Indonesiana, 45(1). https://doi.org/10.33820/mdvi.v45i1.18

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