Gambaran Klinikopatologi Karsinoma Sel Basal di RSUP Dr. Hasan Sadikin Bandung Tahun 2018
Abstrak
Karsinoma Sel Basal (KSB) merupakan jenis karsinoma kulit yang terletak di stratum basalis epidermis, bersifat invasif secara lokal, rekurensi tinggi, namun jarang bermetastasis. Angka kejadian KSB cenderung terus meningkat setiap tahunnya. Pemeriksaan histopatologis menjadi baku emas dalam menegakkan diagnosis KSB. Penelitian ini bertujuan untuk mengetahui gambaran klinikopatologi pasien KSB di RSUP Dr. Hasan Sadikin Bandung tahun 2018. Penelitian ini menggunakan studi desain deskriptif retrospektif terhadap data sekunder, berupa seluruh (total sampling) rekam medis pasien yang didiagnosis KSB di RSUP Dr. Hasan Sadikin Bandung pada periode 1 Januari hingga 31 Desember 2018. Kasus KSB terbanyak terdapat pada kelompok usia 60 tahun (56,3%) dengan rata-rata usia 59,63 15,91 tahun. Jenis kelamin terbanyak adalah wanita (53,1%) dan sebagian besar bekerja sebagai ibu rumah tangga (37,5%). Riwayat pendidikan terbanyak adalah SD dan SLTA (masing-masing 40,6%). Lokasi lesi terbanyak terdapat di kepala dan atau leher (94%); ukuran >2 cm (39,4%); dan soliter (96,9%). KSB risiko rendah (84,9%) dengan subtipe nodular atau solid (36,4%) merupakan gambaran histopatologis terbanyak.
References
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21. Haryanti R, Suwantika A, Abdassah M. Tinjauan bahan berbahaya dalam krim pencerah kulit. Farmaka-Jurnal Unpad. 2018;16(2):214–24.
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24. Sulieman TME, Husain NEOSA. Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients. Open J Pathol. 2017;07(04):67–79.
25. Lara F, Garbers LEF de M, Santamaría JR. Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors. An Bras Dermatol. 2017 Jan 1;92(1):58–62.
2. Carucci JA, Leffell DJ, Pettersen JS. Basal cell carcinoma. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s dermatology in general medicine. 8th ed. New York: The McGraw-Hill; 2012. p. 1294–303.
3. Cameron MC, Lee E, Hibler BP, Barker CA, Mori S, Cordova M, et al. Basal cell carcinoma: epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol. 2019;80(2):303–17.
4. Lara F, Santamaria JR, Garbers LEF de M. Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors. An Bras Dermatol. 2017;92(1):58–62.
5. Asgari MM, Moffet HH, Ray GT, Quesenberry CP. Trends in basal cell carcinoma incidence and identification of high-risk subgroups, 1998-2012. JAMA Dermatology. 2015;151(9):976–81.
6. J. M, Jr. EHE, S. K, C. M, R.M. P, Patterson JW, et al. Basal Cell Carcinoma. In: E. Elder D, Massi D, A.Scolyer R, Willemze R, editors. WHO Classification of Skin Tumours. 4th ed. Lyon, France: International Agency for Research on Cancer (IARC); 2018. p. 26–34.
7. Cipto H SA. Tumor kulit. In: Menaldi S, Bramono K, Indriatmi W, editors. Ilmu penyakit kulit dan kelamin. 7th ed. Jakarta: Badan Penerbit FKUI; 2016. p. 262–76.
8. Wilvestra S, Lestari S, Asri E. Studi retrospektif kanker kulit di Poliklinik Ilmu Kesehatan Kulit dan Kelamin RS Dr. M Djamil Padang periode tahun 2015-2017. J Kesehat Andalas. 2018;7(Supplement 3):47–9.
9. Fakhrosa I, Sutedja EK, Agusni JH, Feriza V, Saraswati NA. Tinjauan Pustaka: Manifestasi Klinis dan Gambaran Dermoskopi pada Karsinoma Sel Basal. Syifa’ Med J Kedokt dan Kesehat. 2018 Mar 1;8(2):54–67.
10. Qureshi A. Skin cancer: burden of disease. In: Lim HW, Rigel DS, Robinson JK, Ross M, Friedman RJ, Cockerell CJ, et al., editors. Cancer of the skin. 2nd ed. Edinburgh: Elsevier Saunders; 2011. p. 40–3.
11. Kadouch DJ, Leeflang M., Elshot YS, Ulrich M, Van der Wal AC, Wolkerstorfer A, et al. Diagnostic accuracy of confocal microscopy imaging versus punch biopsy for diagnosing and subtyping basal cell carcinoma. J Eur Acad Dermatology Venerol. 2017;31(10):1641–8.
12. WHO Department of HIV/AIDS. Consolidated Guidlines on The Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendation for a public health approach. In: WHO. 2nd ed. World Health Organization; 2016.
13. Network NCC. NCCN Clinical Practice Guidlines in Oncology: Basal Cell Skin Cancer NCCN Evidence Blocks. 2019;
14. Toha SS, Rahman A, Mochtar M, Julianto I, Dharmawan N, Mawardi P, et al. Kejadian Karsinoma Sel Basal di RSUD Dr . Moewardi Surakarta Berdasarkan Subtipe Histopatologi menurut Jenis Kelamin, Usia, Lokasi Anatomi, dan Diameter Tumor. 2019;46(4):256–60.
15. Marcelina P. Expression of patched-1 protein in aggressive and nonaggressive basal cell carcinoma. Am J Clin Exp Med. 2016;4(5):122.
16. Holtmann H, Fuhrmann V, Sander K, Sproll C, Kübler NR, Deep Singh D, et al. Histopathological and patient-related characteristics of basal cell carcinomas of the head and neck influencing therapeutic management. Dermatology Reports. 2018;10(2):37–41.
17. Apalla Z, Lallas A, Sotiriou E, Lazaridou E, Ioannides D. Epidemiological trends in skin cancer. Dermatol Pract Concept. 2017 Apr 30;7(2).
18. Callens J, Van Eycken L, Henau K, Garmyn M. Epidemiology of basal and squamous cell carcinoma in Belgium: the need for a uniform and compulsory registration. J Eur Acad Dermatology Venereol. 2016 Nov 1;30(11):1912–8.
19. Kumar S, Mahajan BB, Kaur S, Yadav A, Singh N, Singh A. A Study of Basal Cell Carcinoma in South Asians for Risk Factor and Clinicopathological Characterization: A Hospital Based Study. J Skin Cancer. 2014;2014.
20. Lantara NF. The roles of woman as leader and housewife. J Def Manag. 2015;5(1):1–5.
21. Haryanti R, Suwantika A, Abdassah M. Tinjauan bahan berbahaya dalam krim pencerah kulit. Farmaka-Jurnal Unpad. 2018;16(2):214–24.
22. Yuyucu Karabulut Y. Clinical and histopathological profile of basal cell carcinomas of the head and neck: An analysis of 95 cases. Clin Res Trials. 2015;1(3):80–4.
23. Fahradyan A, Howell A, Wolfswinkel E, Tsuha M, Sheth P, Wong A. Updates on the Management of Non-Melanoma Skin Cancer (NMSC). Healthcare. 2017 Nov 1;5(4):82.
24. Sulieman TME, Husain NEOSA. Clinicopathological Pattern of Basal Cell Carcinoma among Sudanese Patients. Open J Pathol. 2017;07(04):67–79.
25. Lara F, Garbers LEF de M, Santamaría JR. Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors. An Bras Dermatol. 2017 Jan 1;92(1):58–62.
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